Effects of MK-771, a novel TRH analog, on brain dopaminergic and serotonergic systems
Effects of MK-771, a novel TRH analog, on brain dopaminergic and serotonergic systems
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MK-771（一种新型 TRH 类似物）对大脑多巴胺能和血清素能系统的影响
DOI：
10.1016/0014-2999(81)90231-4
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Y. Lapierre
中科院分区：
文献类型：
--
作者：
R. Rastogi;R. L. Singhal;Y. Lapierre
研究了MK-771（一种促甲状腺激素释放激素类似物）急性给药对大鼠脑中多巴胺和5-羟色胺合成和释放的影响。以10和15 mg/kg剂量单次注射MK-771导致纹状体（黑质纹状体多巴胺系统的一个部位）和嗅结节（中脑边缘多巴胺系统的一个部位）中酪氨酸羟化酶活性以及高香草酸水平升高。MK-771给药后，多巴胺水平保持不变（嗅结节、海马）或降低（纹状体、下丘脑、脑桥-髓质）。以15 mg/kg剂量急性注射MK-771使中脑色氨酸羟化酶活性和色氨酸水平分别增加26%和55%。在几个脑区报告了5-羟色胺及其代谢物5-羟基吲哚乙酸水平的一致增加。这些数据表明，MK-771可显著增加脑多巴胺和5-羟色胺的合成和转换。
The effect of acute treatment with MK-771, a thyrotropin-releasing hormone analog, has been investigated on the synthesis and release of dopamine and 5-hydroxytryptamine in rat brain. Single injection of MK-771 in doses of 10 and 15 mg/kg produced a rise in tyrosine hydroxylase activity as well as homovanillic acid level in striatum (a site of nigrostriatal dopamine system) and olfactory tubercles (a site of mesolimbic dopamine system). The dopamine levels remained unchanged (olfactory tubercles, hippocampus) or decreased (striatum, hypothalamus, pons-medulla) after MK-771 treatment. Acute MK-771 injection at the dose of 15 mg/kg increased mid-brain tryptophan hydroxylase activity and tryptophan levels by 26% and 55%, respectively. A consistent increase in the levels of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid was reported in several brain areas. These data suggest that MK-771 elicits a marked increase in the synthesis and turnover of brain dopamine and 5-hydroxytryptamine.