Phencyclidine disrupts long- but not short-term memory within a spatial learning task.
Phencyclidine disrupts long- but not short-term memory within a spatial learning task.
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苯环己哌啶会破坏空间学习任务中的长期记忆，但不会破坏短期记忆。
DOI：
10.1007/bf02257411
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发表时间：
1993
影响因子：
3.4
通讯作者：
Bolland,BL
中科院分区：
文献类型：
--
作者：
Kesner,RP;Dakis,M;Bolland,BL
在第一个实验中，对注射 1、2、3 或 4 mg/kg 苯环己哌啶 (PCP) 或盐水的大鼠进行了奶酪板空间任务（水迷宫的旱地版本）的获取或保留测试。结果表明，相对于对照组或注射 1 和 2 mg/kg 五氯苯酚的大鼠，注射 3 或 4 mg/kg 五氯苯酚的大鼠在任务获取和保留方面受到损害，这通过增加寻找正确食物位置的移动距离来衡量。这种损害主要是在几天之间而非几天内的表现中观察到的。在第二个实验中，测试了注射 4 mg/kg 五氯苯酚或盐水的大鼠在延迟空间匹配样本任务中的记忆表现。结果表明，相对于对照大鼠，注射 4 mg/kg 五氯苯酚在 1-5 或 30 秒延迟后均未受到损害。研究表明，PCP 通过其对 NMDA 受体的阻断作用介导空间位置信息的长期而非短期记忆以及检索先前学习的空间位置信息的能力。
In the first experiment rats with 1, 2, 3 or 4 mg/kg phencyclidine (PCP), or saline injections were tested for acquisition or retention of a cheese board spatial task (dry land version of a water maze). Results indicate that relative to controls or rats with injections of 1 and 2 mg/kg PCP, rats with 3 or 4 mg/kg PCP injections were impaired in acquisition and retention of the task as measured by increased distances traveled to find the correct food location. This impairment was primarily observed in between days but not within days performance. In the second experiment rats with 4 mg/kg PCP or saline injections were tested for memory performance of a delayed spatial matching-to-sample task. Results indicate that relative to controls rats with 4 mg/kg PCP injections were not impaired at either 1–5 or 30 s delays. It is suggested that PCP through its blocking action of the NMDA receptor mediates long- but not short-term memory for spatial location information as well as the ability to retrieve previously learned spatial location information.