WOUND TISSUE CAN UTILIZE A POLYMERIC TEMPLATE TO SYNTHESIZE A FUNCTIONAL EXTENSION OF SKIN
WOUND TISSUE CAN UTILIZE A POLYMERIC TEMPLATE TO SYNTHESIZE A FUNCTIONAL EXTENSION OF SKIN
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DOI：
10.1126/science.7031899
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
SKRABUT, EM
中科院分区：
文献类型：
--
作者：
YANNAS, IV;BURKE, JF;SKRABUT, EM
通过应用双层聚合物膜，实现了豚鼠和人类全层皮肤伤口的迅速和长期闭合。所述膜包括硅酮弹性体的顶层和胶原蛋白和糖胺聚糖的多孔交联网络的底层。底层可以在移植前接种少量自体基底细胞。未使用免疫抑制剂，无感染、渗出和排斥反应。宿主组织利用无菌膜作为培养基来合成新表皮和新真皮组织。在整个伤口区域上形成皮肤的功能性延伸。4周。
Prompt and long-term closure of full-thickness skin wounds in guinea pigs and humans is achieved by applying a bilayer polymeric membrane. The membrane comprises a top layer of a silicone elastomer and a bottom layer of a porous cross-linked network of collagen and glycosaminoglycan. The bottom layer can be seeded with a small number of autologous basal cells before grafting. No immunosuppression is used and infection, exudation and rejection are absent. Host tissue utilizes the sterile membrane as a culture medium to synthesize neoepidermal and neodermal tissue. A functional extension of skin over the entire wound area is formed in .apprx. 4 wk.