Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure.
Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure.
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DOI：
10.1001/jamacardio.2023.2167
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发表时间：
2023-09-01
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影响因子：
24
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中科院分区：
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白细胞端粒长度（LTL）与心血管结构和功能的改变有关吗？在这项包括40459名英国生物样本库参与者的横断面研究中，LTL越长，左心室质量越高，心室和心房尺寸越大，每搏输出量越高。孟德尔随机化分析表明，LTL与左心室质量、心室大小和左心室每搏输出量之间存在潜在的因果遗传关联，在考虑潜在混杂因素后，LTL越长，发生心力衰竭的风险越低。这些发现强调了LTL动力学的调节可能在改善心血管结构和功能方面发挥作用，这可能解释了观察到的心力衰竭未来风险较低的原因。这项横断面研究评估了白细胞端粒长度与心脏大小、功能和心力衰竭之间的关系。较长的白细胞端粒长度（LTL）与较低的心血管不良结局风险相关。LTL变异与中间心血管表型相关的程度尚不清楚。为了评估LTL与一组不同的心血管成像表型之间的相关性，这是一项基于人群的横断面研究，研究对象是2006年至2010年招募的英国生物样本库参与者。使用定量聚合酶链反应方法测量LTL。心血管测量值是使用机器学习从心血管磁共振中获得的。中位（IQR）随访时间为12.0（11.3-12.7）年。通过多变量回归模型评估LTL与影像学测量和心力衰竭（HF）事件的相关性。采用孟德尔随机化方法研究了LTL与显著相关性状之间的遗传关联。数据分析时间为2023年1月至5月。黎巴嫩里拉。心血管影像学特征和HF。在纳入的40459名参与者中，19529名（48.3%）为男性，平均（SD）年龄为55.1（7.6）岁。较长的LTL与积极的心脏重构模式（较高的左心室质量、较大的整体心室大小和容积、较高的心室和心房每搏输出量）和较低的HF事件风险独立相关（LTL第四四分位数vs第一四分位数：风险比，0.86; 95%CI，0.81-0.91; P = 1.8 × 10−6）。孟德尔随机化分析表明LTL与左心室质量、整体心室容积和左心室每搏输出量之间存在潜在的因果关系。在这项横断面研究中，较长的LTL与中年心脏较大、心功能较好相关，这可能解释了观察到的HF事件风险较低。
Is leukocyte telomere length (LTL) associated with alterations in cardiovascular structure and function? In this cross-sectional study including 40 459 UK Biobank participants, longer LTL was associated with higher left ventricular mass, larger ventricular and atrial sizes, and higher stroke volumes. Mendelian randomization analysis demonstrated a potential causal genetic association between LTL and left ventricular mass, ventricular size, and left ventricular stroke volume, and longer LTL was associated with a lower risk of incident heart failure after accounting for potential confounders. These findings highlight that modulation of LTL dynamics may have a role in improving cardiovascular structure and function, which could potentially explain the observed lower future risk of heart failure. This cross-sectional study evaluates the associations between leukocyte telomere length and cardiac size, function, and heart failure. Longer leukocyte telomere length (LTL) is associated with a lower risk of adverse cardiovascular outcomes. The extent to which variation in LTL is associated with intermediary cardiovascular phenotypes is unclear. To evaluate the associations between LTL and a diverse set of cardiovascular imaging phenotypes This is a population-based cross-sectional study of UK Biobank participants recruited from 2006 to 2010. LTL was measured using a quantitative polymerase chain reaction method. Cardiovascular measurements were derived from cardiovascular magnetic resonance using machine learning. The median (IQR) duration of follow-up was 12.0 (11.3-12.7) years. The associations of LTL with imaging measurements and incident heart failure (HF) were evaluated by multivariable regression models. Genetic associations between LTL and significantly associated traits were investigated by mendelian randomization. Data were analyzed from January to May 2023. LTL. Cardiovascular imaging traits and HF. Of 40 459 included participants, 19 529 (48.3%) were men, and the mean (SD) age was 55.1 (7.6) years. Longer LTL was independently associated with a pattern of positive cardiac remodeling (higher left ventricular mass, larger global ventricular size and volume, and higher ventricular and atrial stroke volumes) and a lower risk of incident HF (LTL fourth quartile vs first quartile: hazard ratio, 0.86; 95% CI, 0.81-0.91; P = 1.8 × 10−6). Mendelian randomization analysis suggested a potential causal association between LTL and left ventricular mass, global ventricular volume, and left ventricular stroke volume. In this cross-sectional study, longer LTL was associated with a larger heart with better cardiac function in middle age, which could potentially explain the observed lower risk of incident HF.