DIETARY SATURATED FATTY-ACIDS - A NOVEL TREATMENT FOR ALCOHOLIC LIVER-DISEASE
DIETARY SATURATED FATTY-ACIDS - A NOVEL TREATMENT FOR ALCOHOLIC LIVER-DISEASE
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DOI：
10.1016/0016-5085(95)90344-5
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发表时间：
1995-08-01
期刊：
影响因子：
29.4
通讯作者：
DANNENBERG, AJ
中科院分区：
文献类型：
--
作者：
NANJI, AA;SADRZADEH, SMH;DANNENBERG, AJ
背景和目的：脂质过氧化可能在酒精性肝损伤的发病机制中起重要作用。本研究的目的是确定是否饱和脂肪酸为基础的治疗（棕榈油）可以减少脂质过氧化和酒精性肝损伤在乙醇戒断。方法：雄性Wistar大鼠分为3组（5只/组）。第1组大鼠喂食鱼油-乙醇饮食6周;第2组和第3组大鼠喂食鱼油-乙醇饮食6周，然后用鱼油-葡萄糖（第2组）或棕榈油-葡萄糖（第3组）治疗2周。分析肝脏样本的组织病理学、脂质过氧化、脂肪酸组成、细胞色素P450 2 E1活性和生育酚水平。结果：6周时，所有大鼠均出现脂肪肝、炎症和坏死。第2组显示出最小的组织学改善，而第3组显示出组织学接近正常化。第3组的改善与脂质过氧化和P450 2 E1活性降低有关。在第2组中检测到的omega-3脂肪酸水平高于第3组。各组生育酚水平相似。结论：富含饱和脂肪酸而非不饱和脂肪酸的饮食可逆转酒精性肝损伤。这种影响可能是通过下调脂质过氧化反应来解释的。
Background and Aims: Lipid peroxidation may be important in the pathogenesis of alcoholic liver injury. The purpose of this study was to determine whether a saturated fatty acid-based therapy (palm oil) could decrease lipid peroxidation and alcoholic liver injury during ethanol withdrawal. Methods: Three groups of male Wistar rats (5 rats/group) were studied. Rats in group 1 were fed a fish oil-ethanol diet for 6 weeks; rats in groups 2 and 3 were fed a fish oil-ethanol diet for 6 weeks before treatment with fish oil-dextrose (group 2) or palm oil-dextrose (group 3) for 2 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, fatty acid composition, cytochrome P450 2E1 activity, and tocopherol levels. Results: By 6 weeks, all rats had developed fatty liver, inflammation, and necrosis. Group 2 showed minimal histological improvement, whereas group 3 showed near normalization of the histology. The improvement in group 3 was associated with decreased lipid peroxidation and P450 2E1 activity. Higher levels of omega-3 fatty acids were detected in group 2 than group 3. Tocopherol levels were similar among the groups. Conclusions: A diet enriched in saturated but not unsaturated fatty acids reversed alcoholic liver injury. This effect may be explained by down-regulation of lipid peroxidation.