Applications of Human Pluripotent Stem Cell-Derived Skin Organoids in Dermatology.
Applications of Human Pluripotent Stem Cell-Derived Skin Organoids in Dermatology.
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人类多能干细胞衍生的皮肤类器官在皮肤病学中的应用。
DOI：
10.1016/j.jid.2023.07.017
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Koehler,KarlR
中科院分区：
文献类型：
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作者：
Sandoval,AaronGabrielW;Gim,KellyY;Huang,JenniferT;Koehler,KarlR
多能干细胞具有成为任何细胞类型的潜力，最近，它们已被用于创建可以概括人体器官的几个相关特征的类器官。已经开发出具有许多关键附属器官的皮肤类器官，包括毛囊、皮脂腺、神经、脂肪和黑素细胞。这些皮肤类器官提供了研究皮肤发育和疾病的机会，并进行筛选以识别新的候选药物。在未来，皮肤类器官可能会通过作为移植治疗伤口或其他疾病的源材料来增强临床实践。然而，在实现皮肤类器官的全部潜力之前，必须首先解决几个限制，例如可能导致异质产品的冗长的分化方案。本文的目的是提供皮肤类器官的广泛概述，以便更广泛的受众可以熟悉这项技术，这对皮肤病学研究和医学具有重要意义。
Pluripotent stem cells have the potential to become any cell type, and recently, they have been used to create organoids that can recapitulate several pertinent features of human organs. Skin organoids have been developed that possess many of the crucial accessory organs, including hair follicles, sebaceous glands, nerves, fat, and melanocytes. These skin organoids present the opportunity to study skin development and disease as well as perform screens to identify new drug candidates. In the future, skin organoids might augment clinical practice by serving as source material for transplantation to treat wounds or other conditions. Nevertheless, several limitations, such as the lengthy differentiation protocol, which can result in heterogeneous products, must first be addressed before the full potential of skin organoids can be realized. The purpose of this article is to provide a broad overview of skin organoids so that a broader audience can become familiar with this technology, which has important implications for dermatologic research and medicine.