Biological surface science
Biological surface science
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DOI：
10.1016/s0039-6028(01)01809-x
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发表时间：
2002-03-10
期刊：
影响因子：
1.9
通讯作者：
Kasemo, B
中科院分区：
文献类型：
--
作者：
Kasemo, B
生物表面科学（BioSS），在此定义为一个广泛的跨学科领域，该领域研究合成材料与生物环境之间界面的性质和过程，并制造生物功能表面。本文用六个例子来介绍和讨论这一主题：人体内的医用植入物、用于诊断的生物传感器和生物芯片、组织工程、生物电子学、人工光合作用以及仿生材料。它们处于不同的成熟阶段，共同构成了当前生物表面科学快速发展的强大驱动力。第二个驱动力是探索生物组分与表面之间相互作用所带来的纯科学挑战和机遇。模型系统涵盖从固体表面独特的水结构以及蛋白质和生物膜周围的水壳，到氨基酸、核酸、蛋白质、DNA、磷脂膜，再到表面的细胞和活组织。在这个复杂程度范围的一端，科学挑战是以类似于过去三十年表面科学中对简单分子所做的方式，绘制出表面生物分子的结构、键合、动力学和动态学。在复杂程度范围的另一端，人们要解决生物功能表面如何参与以及如何被设计为对细胞和组织的整个通讯系统有建设性参与的问题。生物功能表面需要先进的设计和制备，以匹配生物系统复杂的（生物）识别能力。具体而言，这需要表面上的地形、化学和粘弹性模式相结合，以在纳米尺度上匹配蛋白质，在微米尺度上匹配细胞。基本上表面科学的所有方法都是有用的。高分辨率（例如扫描探针）显微镜、空间分辨且高灵敏度的非侵入性光学光谱学、自组装单分子层以及纳米和微制造对生物表面科学都很重要。然而，也需要采用或开发新的方法来研究天然液态的生物界面。未来，生物表面科学可能会有比上述更广泛的定义，包括天然界面，并且分子（细胞）生物学和生物表面科学的结合将有助于对“生命状态”的理解。（C）2001爱思唯尔科学出版社。保留所有权利。
Biological surface science (BioSS), as defined here is the broad interdisciplinary area where properties and processes at interfaces between synthetic materials and biological environments are investigated and biofunctional surfaces are fabricated. Six examples are used to introduce and discuss the subject: Medical implants in the human body, biosensors and biochips for diagnostics, tissue engineering, bioelectronics, artificial photosynthesis, and biomimetic materials. They are areas of varying maturity, together constituting a strong driving force for the current rapid development of BioSS. The second driving force is the purely scientific challenges and opportunities to explore the mutual interaction between biological components and surfaces.Model systems range from the unique water structures at solid surfaces and water shells around proteins and biomembranes, via amino and nucleic acids, proteins, DNA, phospholipid membranes. to cells and living tissue at surfaces. At one end of the spectrum the scientific challenge is to map out the structures, bonding, dynamics and kinetics of biomolecules at surfaces in a similar way as has been done for simple molecules during the past three decades in surface science. At the other end of the complexity spectrum one addresses how biofunctional surfaces participate in and can be designed to constructively participate in the total communication system of cells and tissue.Biofunctional surfaces call for advanced design and preparation in order to match the sophisticated (bio) recognition ability of biological systems. Specifically this requires combined topographic, chemical and visco-clastic patterns on surfaces to match proteins at the nm scale and cells at the micrometer scale. Essentially all methods of surface science are useful. High-resolution (e.g. scanning probe) microscopies. spatially resolved and high sensitivity, non-invasive optical spectroscopies, self-organizing monolayers, and nano- and microfabrication are important for BioSS. However, there is also a need to adopt or develop new methods for studies of biointerfaces in the native, liquid state.For the future it is likely that BioSS will have an even broader definition than above and include native interfaces, and that combinations of molecular (cell) biology and BioSS will contribute to the understanding of the "living state". (C) 2001 Elsevier Science B.V. All rights reserved.