Recent experience with Pseudomonas aeruginosa bacteremia in patients with cancer -: Retrospective analysis of 245 episodes
Recent experience with Pseudomonas aeruginosa bacteremia in patients with cancer -: Retrospective analysis of 245 episodes
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DOI：
10.1001/archinte.160.4.501
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发表时间：
2000-02-28
影响因子：
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通讯作者：
Samonis, G
中科院分区：
文献类型：
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作者：
Chatzinikolaou, I;Abi-Said, D;Samonis, G
背景资料：铜绿假单胞菌菌血症是一个严重的和可能致命的条件，在cancer. Objective. To确定的频率，人口统计学，和易感因素铜绿假单胞菌菌血症的癌症患者，并确定各种治疗regiments.Subjects和方法的疗效：临床微生物学实验室，得克萨斯大学，M。D.安德森癌症中心，休斯顿，进行了审查。从1991年1月1日至1995年12月31日，确定了245例符合条件的铜绿假单胞菌菌血症病例。我们检查了患者的记录，包括潜在的恶性肿瘤及其治疗、感染的症状和体征、适当标本的培养结果、抗生素治疗和结局。我们还将我们目前的经验与该机构之前的分析（涵盖1972年1月1日至1981年12月31日）进行了比较。结果：与之前的研究相比，铜绿假单胞菌菌血症的发生率有所下降（每1000名入院者中有2.8例与4.7例病例）。它在急性白血病患者中最常见（1000例登记中有55例），并且在这种疾病中的频率没有变化。一半的病人在感染时并不在医院。总治愈率为80%，与对照组比较有显著性差异（P
Background: Pseudomonas aeruginosa bacteremia is a serious and possibly fatal condition in patients with cancer.Objectives: To ascertain the frequency, demographics, and predisposing factors for P aeruginosa bacteremia in patients with cancer and to determine the efficacy of various therapeutic regimens.Subjects and Methods: Patient records of the Clinical Microbiology Laboratory, The University of Texas, M. D. Anderson Cancer Center, Houston, were reviewed. From January 1, 1991, through December 31, 1995, 245 eligible cases of P aeruginosa bacteremia were identified. We examined the patient records for the underlying malignant neoplasm and its management, symptoms and signs of infection, culture results of appropriate specimens, antibiotic therapy, and outcome. We also compared our present experience with a previous analysis from this institution covering the period from January 1, 1972, to December 31,1981.Results: The incidence of P aeruginosa bacteremia has decreased compared with the previous study (2.8 vs 4.7 cases per 1000 admissions). It was most common in patients with acute leukemia (55 of 1000 registrations), and the frequency in this disease has not changed. Half of the patients were not in the hospital when they developed their infection. The overall cure rate was 80%, which was a significant (P