POTENTIAL ALUMINUM TOXICITY IN INFANTS FED SPECIAL INFANT FORMULA
POTENTIAL ALUMINUM TOXICITY IN INFANTS FED SPECIAL INFANT FORMULA
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DOI：
10.1097/00005176-199411000-00002
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发表时间：
1994-11-01
影响因子：
2.9
通讯作者：
DELVES, HT
中科院分区：
文献类型：
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作者：
HAWKINS, NM;COFFEY, S;DELVES, HT
铝的血浆样品和样品的饲料从74名婴儿与正常的肾功能建立在各种饲料（母乳，乳清为基础的，强化乳清为基础的，早产儿，大豆，酪蛋白水解物）。所有的婴儿都进行了大剂量喂养，并在喂养的中途收集了血液样本。铝的测定采用火焰原子化和原子吸收光谱法。牛奶中的平均铝浓度如下：母乳，9.2 μ g/L [95%置信区间（CI），5.6-12.7];乳清，165 μ g/L（95% CI，151-180）;加标，161 μ g/L（95% CI，143-180）;早产儿，300 μ g/L（95% CI，272-328）;大豆，534 μ g/L（95% CI，470-598）;酪蛋白水解物，773 μ g/L（95% CI，632-914）。接受不同牛奶的婴儿的平均血浆铝浓度如下：乳房，8.6 μ g/L（95% CI，5.6-10.6）;乳清，9.2 μ g/L（95% CI，7.4-11.0）;加标，10.3 μ g/L（95% CI，8.3-12.3）;早产儿，9.7 μ g/L（95% CI，5.3-17.1）;大豆，12.5 μ g/L（95% CI，5.0-20.0）;水解酪蛋白，15.2 μ g/L（95% CI，10.7-19.8）。酪蛋白水解物配方奶粉喂养的婴儿与母乳喂养的婴儿的平均血浆铝浓度存在显著差异（差异为6.7 μ g/L; 95%CI，2.8-10.5; p = 0.028）。我们的结论是，当婴儿食用含有>300 μ g/L的配方奶粉时，特别是酪蛋白水解物配方奶粉，可能有铝中毒的风险。我们推测，母乳中发现的铝化合物比其他牛奶中发现的铝化合物生物利用度更高，婴儿配方奶粉中的某些成分会影响肠腔对铝的吸收。
Aluminium was measured in samples of plasma and samples of feed obtained from 74 infants with normal renal function established on various feeds (breast, whey-based, fortified whey-based, preterm, soy, and casein hydrolysate). All infants were bolus fed, and blood samples were collected midway between feeds. Aluminium was measured using electrothermal atomization and atomic absorption spectrometry. Mean aluminium concentrations in milks were as follows: breast, 9.2 mu g/L [95% confidence interval (CI), 5.6-12.7]; whey-based, 165 mu g/L (95% CI, 151-180); fortified, 161 mu g/L (95% CI, 143-180); preterm, 300 mu g/L (95% CI, 272-328); soy, 534 mu g/L (95% CI, 470-598); casein hydrolysate, 773 mu g/L (95% CI, 632-914). Mean plasma aluminium concentrations in infants receiving different milks were as follows: breast, 8.6 mu g/L (95% CI, 5.6-10.6); whey-based, 9.2 mu g/L (95% CI, 7.4-11.0); fortified, 10.3 mu g/L (95% CI, 8.3-12.3); preterm, 9.7 mu g/L (95% CI, 5.3-17.1); soy, 12.5 mu g/L (95% CI, 5.0-20.0); casein hydrolysate, 15.2 mu g/L (95% CI, 10.7-19.8). Mean plasma aluminium concentration was significantly different in infants fed casein hydrolysate formulae than in those fed breast milk (difference, 6.7 mu g/L; 95% CI, 2.8-10.5; p = 0.028). We conclude that infants may be at risk from aluminium toxicity when consuming formula containing >300 mu g/L-in particular, casein hydrolysate formulae. We speculate that the aluminium compounds found in breast milk are more bioavailable than those found in other milks and that some constituents of infant formula affect aluminium absorption from the gut lumen.