Oxidant-antioxidant balance in acute lung injury
Oxidant-antioxidant balance in acute lung injury
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DOI：
10.1378/chest.122.6_suppl.314s
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发表时间：
2002-12-01
期刊：
影响因子：
9.6
通讯作者：
Matalon, S
中科院分区：
文献类型：
--
作者：
Lang, JD;McArdle, PJ;Matalon, S
ARDS 是一种以肺实质弥漫性炎症为特征的疾病过程。炎症介质在ARDS中的参与一直是深入研究的主题，(1,2)并且氧化剂介导的组织损伤可能在ARDS的发病机制中很重要。(3)响应于各种炎症刺激，肺内皮细胞、肺泡细胞和气道上皮细胞以及活化的肺泡巨噬细胞产生一氧化氮和超氧化物，它们可能反应形成过氧亚硝酸盐，过氧亚硝酸盐可以硝酸盐氧化各种肺蛋白中的关键氨基酸，例如表面活性蛋白A，并抑制其功能。肺泡腔中存在的多种关键蛋白质的硝化和氧化已被证明与体外功能减弱有关，并且在从急性肺损伤 (ALI)/ARDS 患者中采集的蛋白质样本中也已被体外鉴定。各种各样的。肺组织和肺泡衬液中存在的酶和低分子量清除剂降低了这些有毒物质的浓度。本章的目的是回顾各种研究的结果，这些研究表明 ALI/ARDS 患者肺泡腔中活性氧-氮中间体水平升高。
ARDS is a disease process that is characterized by diffuse inflammation in the lung parenchyma. The involvement of inflammatory mediators in ARDS has been the subject of intense investigation,(1,2) and oxidant-mediated tissue injury is likely to be important in the pathogenesis of ARDS.(3) In response to various inflammatory stimuli, lung endothelial cells, alveolar cells, and airway epithelial cells, as well as activated alveolar macrophages, produce both nitric oxide and super-oxide, which may react to form peroxynitrite, which can nitrate and oxidize key amino acids in various lung proteins, such as surfactant protein A, and inhibit their functions. The nitration and oxidation of a variety of crucial proteins present in the alveolar space have been shown to be associated with diminished function in vitro and also have been identified ex vivo in proteins sampled from patients with acute lung injury (ALI)/ARDS. Various. enzymes and low-molecular-weight scavengers that are present in the lung tissue and alveolar lining fluid decreased the concentration of these toxic species. The purpose of this brief chapter is to review the results from various studies demonstrating increased levels of reactive oxygen-nitrogen intermediates in the alveolar spaces of patients with ALI/ARDS.