FREE-BASE COCAINE SMOKING
FREE-BASE COCAINE SMOKING
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DOI：
10.1038/clpt.1982.189
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发表时间：
1982-01-01
影响因子：
6.7
通讯作者：
COOK, CE
中科院分区：
文献类型：
--
作者：
PEREZREYES, M;DIGUISEPPI, S;COOK, CE
六名健康的男性受试者，在严格控制的吸烟协议下，在一个特别设计的玻璃管中吸食50毫克的游离碱可卡因。通过实验确定了加热管道的方法和产生最有效和一致的药物蒸发的温度。记录了吸食游离基可卡因对心理和心血管的影响。吸烟后，大约26%的原始材料从烟斗中回收。体外模拟吸烟实验表明，在未被困在烟斗中的物质中，只有44%是可卡因，其中约90%的可卡因是在前4口（即在模拟吸烟的前2分钟）中输送的。这些发现表明，在最初放置在烟斗碗中的50毫克不含可卡因的碱中，只有32%可以被吸入。0.6毫克)。吸入不含可卡因的碱对心理和心血管的影响与同样的受试者静脉注射20毫克盐酸可卡因（18毫克可卡因碱）的效果相似，或者比前者更强烈、更愉悦，而且还引起了对另一剂量的更强烈的渴望。
Six healthy male, paid subjects smoked 50 mg of free-base cocaine in a specially designed glass pipe under a rigidly controlled smoking protocol. The method of heating the pipe and the temperature that produced the most efficient and consistent vaporization of the drug had been determined experimentally. The psychological and cardiovascular effects of smoking free-base cocaine were recorded. Approximately 26% of the original material was recovered from the pipe after smoking. Simulated smoking experiments in vitro indicated that only 44% of the material not trapped in the pipe was cocaine and that > 90% of this cocaine was delivered during the first 4 puffs (i.e., during the first 2 min of simulated smoking). These findings indicate that of the original 50 mg of cocaine free base placed in the pipe''s bowl, only 32% could have been inhaled (16.3 .+-. 0.6 mg). The cocaine free base inhaled induced psychological and cardiovascular effects similar to, or slightly more intense and pleasurable than, the effects of 20 mg of cocaine hydrochloride (18 mg of cocaine base) taken i.v. by the same subjects and also induced a slightly more intense craving for another dose.