Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa.
Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa.
复制标题
合成心房钠尿因子对牛肾上腺肾小球的作用。
DOI：
10.1016/0024-3205(84)90179-6
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发表时间：
1984
期刊：
影响因子：
6.1
通讯作者：
Atlas,SA
中科院分区：
文献类型：
--
作者：
Goodfriend,TL;Elliott,ME;Atlas,SA
合成心房利钠因子(ANF)抑制牛肾上腺肾小球细胞悬浮培养产生的醛固酮。当测量基础醛固酮的产生时，ANF的抑制作用最为明显。ANF对血管紧张素II(AII)、N6，O2‘-二丁酰环一磷酸(2’：5‘-cAMP)和高钾的作用也有抑制作用。大剂量的激动剂可部分克服抑制作用。抑制作用局限于醛固酮生成的早期途径，直到胆固醇侧链断裂之前的一步。ANF不影响AII与受体的结合，也不影响AII刺激磷脂转换，也不影响AII改变钙离子流量。
Synthetic atrial natriuretic factor (ANF) inhibited aldosterone production by suspensions of bovine adrenal glomerulosa cells. Inhibition by ANF was most pronounced when basal aldosterone production was measured. The effects of angiotensin II (AII), N6, O2′-dibutyryl-adenosine 3′:5′-cyclic monophosphate (dibutyryl cyclic AMP), and elevated potassium were also inhibited by ANF. Inhibition could be partially overcome by high doses of agonist. Inhibition was localized to the early pathway of aldosterogenesis, to a step before cholesterol side-chain cleavage. ANF had no effect on binding of AII to receptors, on the stimulation by AII of phospholipid turnover, or on the alteration by AII of calcium fluxes.