INTRAVENOUS-INJECTION OF ALBUNEX MICROSPHERES CAUSES THROMBOXANE MEDIATED PULMONARY-HYPERTENSION IN PIGS, BUT NOT IN MONKEYS OR RABBITS
INTRAVENOUS-INJECTION OF ALBUNEX MICROSPHERES CAUSES THROMBOXANE MEDIATED PULMONARY-HYPERTENSION IN PIGS, BUT NOT IN MONKEYS OR RABBITS
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DOI：
10.1111/j.1748-1716.1992.tb09299.x
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发表时间：
1992-03-01
期刊：
影响因子：
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通讯作者：
HOLTZ, E
中科院分区：
文献类型：
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作者：
OSTENSEN, J;HEDE, R;HOLTZ, E
静脉注射超声造影剂Albunex(R)（由挪威奥斯陆的Nycomed AS公司生产，每毫升4亿个充气白蛋白微球，平均直径4 +/- 1 μ m）导致9头猪平均肺动脉压呈剂量依赖性升高。最高剂量（0.014 +/- 0.002 ml kg-1）使平均肺动脉压从17 +/- 1 mmHg增加到42 +/- 3 mmHg，平均全身动脉压从111 +/- 9降低到93 +/- 12 mmHg。压力响应在注入颗粒后22 +/- 1 s开始，51 +/- 3 s后达到最大值。在吲哚美辛（10mg kg-1 + 5mg kg-1 h-1静脉注射，n = 6）或血栓素A2受体拮抗剂HN-11500 （10mg kg-1 + 5mg kg-1 h-1静脉注射，n = 3）治疗期间，注射Albunex后平均肺动脉压和平均全身动脉压均无变化。吲哚美辛治疗期间注射0.12 ml kg-1 Albunex(R)后，颈动脉未见多普勒增强。在5只家兔中，Albunex(R)引起颈动脉多普勒增强，0.48 ml kg-1不影响5只家兔或3只食蟹猴的平均肺动脉压或其他血流动力学参数。猪的压力反应可能是由肺血管内巨噬细胞在吞噬微球时释放血栓素A2来解释的。兔和猴对Albunex(R)完全没有这种反应。
Intravenous injection of the ultrasound contrast agent Albunex(R) (manufactured by Nycomed AS, Oslo, Norway; 400 million air-filled albumin microspheres per ml, mean diameter 4 +/- 1-mu-m) caused a dose-dependent increase of mean pulmonary arterial pressure in nine pigs. The highest dose (0.014 +/- 0.002 ml kg-1) increased mean pulmonary arterial pressure from 17 +/- 1 mmHg to 42 +/- 3 mmHg and decreased mean systemic arterial pressure from 111 +/- 9 to 93 +/- 12 mmHg. The pressure responses began 22 +/- 1 s after particle injection, and reached maximum after 51 +/- 3 s. No changes in mean pulmonary arterial pressure or mean systemic arterial pressure were observed after Albunex(R) injections during treatment with indomethacin (10 mg kg-1 +5 mg kg-1 h-1 i.v., n = 6) or the thromboxane A2 receptor antagonist HN-11500 (10 mg kg-1 + 5 mg kg-1 h-1 i.v., n = 3). No Doppler enhancement could be detected in a carotid artery following injection of 0.12 ml kg-1 Albunex(R) during indomethacin treatment. In five rabbits, Albunex(R) caused Doppler enhancement in a carotid artery, and 0.48 ml kg-1 did not affect mean pulmonary arterial pressure or other haemodynamic parameters in five rabbits or in three cynomolgus monkeys. The pressure response in pigs may be explained by release of thromboxane A2 from the pulmonary intravascular macrophages during phagocytosis of the microspheres. This response to Albunex(R) was totally absent in rabbits and monkeys.