A clinical study of odontogenic keratocyst
A clinical study of odontogenic keratocyst
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牙源性角化囊肿的临床研究
DOI：
10.5794/jjoms.49.93
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
T. Amagasa
中科院分区：
文献类型：
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作者：
N. Uzawa;I. Kiyosaki;M. Mori;Takafumi Yamada;H. Yoshimasu;T. Amagasa
牙源性角化囊肿（OKC）是一种起源于牙源性器官（如釉质器官和牙板）的发育性囊肿。OKC的主要组织学特征是囊壁角化，有时包括上皮岛，可能代表薄上皮衬里中的子囊。在临床上，这种疾病的特点是高频率的recurrence.In这项回顾性研究中，我们检查了91 OKC治疗的颌面外科，研究生院，东京医科齿科大学医院在1981年和1995年之间。患者年龄7 ~ 69岁（平均30.5岁），男性50例，女性41例。最常见的部位是磨牙区和下颌支。大多数发生在上颌骨的OKC均行眼球摘除和一期闭合术。下颌区域的大多数OKC被摘除，伤口保持开放。在两名下颌骨出现大病变的患者中进行了下颌骨边缘切除术。术后随访2年以上的61个囊肿中，52个囊肿（85%）无复发，9个囊肿（15%）复发。复发发生在牙根附近，大多数患者没有与复发相关的症状。4例术后10年以上复发。我们的研究结果表明，长期随访和仔细治疗的病变与牙根的OKC患者是必要的。
Odontogenic keratocyst (OKC) is classified as a developmental cyst derived from odontogenic organs such as enamel organs and dental lamina. The main histological feature of OKCs is keratinization in the cyst wall, sometimes including islands of epithelium that may represent daughter cysts in a thin epithelium lining. Clinically, this disease is characterized by a high frequency of recurrence.In this retrospective study, we examined 91 OKCs treated at the Department of Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University Hospital between 1981 and 1995. The ages of the patients ranged from 7 to 69 years (mean age, 30.5), and 50 were male and 41 were female. The most common sites were the molar region and ramus of the mandible. Most of the OKCs in the maxillary region were treated by enucleation and primary closure. Most OKCs in the mandibular region were enucleated, and the wound was left open. Marginal mandibulectomy was performed in two patients with large lesions arising in the mandible. The postoperative course was uneventful in 52 cysts (85%), and recurrence occurred in 9 cysts (15%) among 61 cysts followed-up for more than 2 years. Recurrence occurred near the roots of teeth.In most patients, no symptoms were associated with recurrence. Recurrence occurred in 4 patients more than 10 years after operation. Our findings indicate that long-term follow-up and careful treatment of lesions continguous with the roots of teeth are required in patients with OKCs.