The free energy cost of accurate biochemical oscillations.
The free energy cost of accurate biochemical oscillations.
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DOI：
10.1038/nphys3412
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发表时间：
2015-09
期刊：
影响因子：
19.6
通讯作者：
Tu Y
中科院分区：
文献类型：
--
作者：
Cao Y;Wang H;Ouyang Q;Tu Y
振荡是一个重要的细胞过程，调节不同生命周期的时间。然而，在嘈杂的蜂窝环境中，由于相位波动，振荡可能非常不准确。生物化学回路如何抑制相位波动以及所产生的热力学成本是什么，人们仍然知之甚少。在这里，我们研究了三种不同类型的生化振荡代表三个基本的振荡图案共享所有已知的振荡系统。在所有的系统研究中，我们发现，相扩散常数取决于每周期的自由能耗散以下相同的反关系参数化的系统特定的常数。这种关系和它的有效性范围内示出了分析在一个模型的噪声振荡。从微观上看，我们发现振荡是由水解ATP等燃料分子的多个不可逆循环驱动的;相相干周期的数量与每个周期消耗的自由能成正比。实验证据支持这种一般的关系和可检验的预测。
Oscillation is an important cellular process that regulates timing of different vital life cycles. However, in the noisy cellular environment, oscillations can be highly inaccurate due to phase fluctuations. It remains poorly understood how biochemical circuits suppress phase fluctuations and what is the incurred thermodynamic cost. Here, we study three different types of biochemical oscillations representing three basic oscillation motifs shared by all known oscillatory systems. In all the systems studied, we find that the phase diffusion constant depends on the free energy dissipation per period following the same inverse relation parameterized by system specific constants. This relationship and its range of validity are shown analytically in a model of noisy oscillation. Microscopically, we find that the oscillation is driven by multiple irreversible cycles that hydrolyze the fuel molecules such as ATP; the number of phase coherent periods is proportional to the free energy consumed per period. Experimental evidence in support of this general relationship and testable predictions are also presented.