Enhanced IL-6 Production in Aquaporin-4 Antibody Positive Neuromyelitis Optica Patients
Enhanced IL-6 Production in Aquaporin-4 Antibody Positive Neuromyelitis Optica Patients
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DOI：
10.3109/00207450903428970
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Akman-Demir, Guelsen
中科院分区：
文献类型：
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作者：
Icoz, Sema;Tuzun, Erdem;Akman-Demir, Guelsen
抗水通道蛋白-4（Aqp-4）抗体和补体系统已成为视神经肌萎缩症（NMO）的主要致病因素。为了检测另一种重要的体液免疫因子白细胞介素-6（IL-6）在NMO发病机制中的意义，我们检测了23例NMO、11例横肌炎、16例视神经炎、27例复发缓解型多发性硬化患者和20例神经系统正常对照者的血清和脑脊液（CSF）IL-6水平。NMO和横肌萎缩症患者血清和CSF IL-6水平高于其他组。特别地，抗Aqp-4阳性NMO患者（n = 12）比抗Aqp-4阴性患者（n = 11）具有更高的血清/CSF IL-6水平，并且CSF IL-6水平与抗Aqp-4水平和NMO患者的疾病严重程度相关。我们的研究结果表明，IL-6可能通过抗Aqp-4相关机制参与NMO发病机制。
Anti-aquaporin-4 (Aqp-4) antibody and complement system have emerged as major pathogenic factors in neuromyelitis optica (NMO). To test the significance of interleukin-6 (IL-6), another important humoral immunity factor, in NMO pathogenesis, we measured serum and cerebrospinal fluid (CSF) IL-6 levels of 23 NMO, 11 transverse myelitis, 16 optic neuritis, 27 relapsing remitting multiple sclerosis patients, and 20 neurologically normal controls. NMO and transverse myelitis patients had higher serum and CSF IL-6 levels than other groups. Particularly, anti-Aqp-4 positive NMO patients (n = 12) had higher serum/CSF IL-6 levels than anti-Aqp-4 negative patients (n = 11) and CSF IL-6 levels correlated with anti-Aqp-4 levels and disease severity of the NMO patients. Our results suggest that IL-6 is involved in NMO pathogenesis presumably via anti-Aqp-4 associated mechanisms.