Pharmacokinetics and residues of ciprofloxacin and its metabolites in broiler chickens
Pharmacokinetics and residues of ciprofloxacin and its metabolites in broiler chickens
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DOI：
10.1053/rvsc.2001.0494
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发表时间：
2001-10-01
影响因子：
2.4
通讯作者：
Martínez, M
中科院分区：
文献类型：
--
作者：
Anadón, A;Martínez-Larrañaga, MR;Martínez, M
研究了环丙沙星及其代谢物在健康鸡体内单次静脉注射和口服8 mg环丙沙星（kg（-1）体重）后的药代动力学特性。经静脉和口服给药后，血药浓度-时间图呈双室开放模型。静脉给药后环丙沙星在血浆中的平均消除半衰期（SD）和平均停留时间分别为8.84（2.13）和8.54（1.64）小时，11.89（1.95）和13.32（2.65）小时。口服后。环丙沙星平均最大血药浓度为2.63（0.20）马克毫升（-1），口服给药至最大血药浓度间隔为0.36（0.07）小时。环丙沙星的平均口服生物利用度为69.12(6.95)%，主要转化为氧环丙沙星和去乙基环丙沙星。连续3天口服环丙沙星（8 mg kg(-1)）时，肾脏、肝脏、肌肉和皮肤+脂肪组织中环丙沙星及其代谢物氧环丙沙星和去乙基环丙沙星的浓度相当高。据估计，环丙沙星及其代谢物的平均组织浓度在0.011至0.75马克克（-1）之间持续了5天。(C) 2001哈考特出版有限公司
The pharmacokinetic properties of ciprofloxacin and its metabolites were determined in healthy chickens after single i.v. and oral dosage of 8 mg ciprofloxacin kg(-1) bodyweight. After i.v. and oral administration, the plasma concentration-time graph was characteristic of a two-compartment open model. Mean (SD) elimination half-life and mean residence time of ciprofloxacin in plasma were 8.84 (2.13) and 8.54 (1.64) hours, respectively, after i.v. administration and 11.89 (1.95) and 13.32 (2.65) hours, respectively. after oral administration. Mean maximal plasma concentration of ciprofloxacin was 2.63 (0.20) mug ml(-1), and the interval from oral administration until maximum concentration was 0.36 (0.07) hours. The mean oral bioavailability of ciprofloxacin was found to be 69.12 (6.95) per cent. Ciprofloxacin was mainly converted to oxociprofloxacin and desethyleneciprofloxacin. Considerable kidney, liver, muscle and skin + fat tissue concentrations of ciprofloxacin and its metabolites oxociprofloxacin and desethyleneciprofloxacin were found when ciprofloxacin was administered orally (8 mg kg(-1) on 3 successive days). It was estimated that mean tissue concentrations of ciprofloxacin and its metabolites ranging between 0.011 to 0.75 mug g(-1) persisted for 5 days. (C) 2001 Harcourt Publishers Ltd.