Noninvasive neuromodulation reduces symptoms of restless legs syndrome
Noninvasive neuromodulation reduces symptoms of restless legs syndrome
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DOI：
10.5664/jcsm.9404
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发表时间：
2021-08-01
影响因子：
4.3
通讯作者：
Charlesworth, Jonathan D.
中科院分区：
文献类型：
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作者：
Buchfuhrer, Mark J.;Baker, Fiona C.;Charlesworth, Jonathan D.
研究目的：不宁腿综合征（RLS）是一种常见的神经系统疾病，其特征是在夜间无法控制地想要移动双腿，并且常常伴有慢性睡眠障碍。不宁腿综合征最常见的治疗方法是药物治疗，但药物可能会有使人虚弱的副作用。在此，我们评估了一种新的不宁腿综合征替代治疗方式，即对腓总神经进行无创双侧电刺激。
方法：为了评估这种无创外周神经刺激（NPNS）方法对不宁腿综合征症状的影响，我们进行了一项多中心随机交叉研究，将NPNS与假刺激进行比较。患有中重度不宁腿综合征的患者（n = 37）按照随机顺序，每晚自行进行NPNS和假刺激治疗，每种治疗持续14天。
结果：与假刺激在国际不宁腿综合征评定量表上的3.38分相比，NPNS使不宁腿综合征的严重程度降低了6.81分（P <...此处原文似乎不完整）
Study Objectives: Restless legs syndrome (RLS) is a common neurological disorder characterized by an uncontrollable nocturnal urge to move the legs and often associated with chronic sleep disturbances. The most common treatments for RLS are medications that can have debilitating side effects. Here, we evaluated a novel alternative modality of RLS treatment, noninvasive bilateral electrical stimulation of the common peroneal nerve.Methods: To assess the impact of this noninvasive peripheral nerve stimulation (NPNS) approach to RLS symptomatology, we conducted a multisite randomized crossover study comparing NPNS to sham. RLS patients with moderate-to-severe RLS (n = 37) self-administered NPNS and sham nightly for 14 days per treatment in randomized order.Results: NPNS resulted in a reduction in RLS severity of 6.81 points on the International RLS Rating Scale relative to 3.38 for sham (P