Functional activation in motor cortex reflects the direction and the degree of handedness
Functional activation in motor cortex reflects the direction and the degree of handedness
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DOI：
10.1073/pnas.94.25.14015
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发表时间：
1997-12-09
影响因子：
11.1
通讯作者：
Ashe, J
中科院分区：
文献类型：
--
作者：
Dassonville, P;Zhu, XH;Ashe, J
惯用手是人类行为偏侧化的最明显的例子。目前尚不清楚手部偏好所表现出的明显不对称是否与运动过程中大脑激活的类似不对称有关。我们检查了右手和左手受试者组中惯用手和非惯用手运动期间皮层运动区的功能激活，发现惯用手的使用与对侧运动皮层中更大的激活量相关。此外，惯用手的程度和运动皮层功能偏侧化的程度之间存在单独的关系。与惯用手的方向和程度相关的功能激活模式表明，这些方面是独立的，并且在大脑中单独编码。
Handedness is the dearest example of behavioral lateralization in humans. It is not known whether the obvious asymmetry manifested by hand preference is associated with similar asymmetry in brain activation during movement. We examined the functional activation in cortical motor areas during movement of the dominant and nondominant hand in groups of right-handed and left-handed subjects and found that use of the dominant hand was associated with a greater volume of activation in the contralateral motor cortex. Furthermore, there was a separate relation between the degree of handedness and the extent of functional lateralization in the motor cortex. The patterns of functional activation associated with the direction and degree of handedness suggest that these aspects are independent and are coded separately in the brain.