Equilibrium swelling and kinetics of pH-responsive hydrogels: Models, experiments, and simulations
Equilibrium swelling and kinetics of pH-responsive hydrogels: Models, experiments, and simulations
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DOI：
10.1109/jmems.2002.803281
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发表时间：
2002-10-01
影响因子：
2.7
通讯作者：
Moore, J
中科院分区：
文献类型：
--
作者：
De, SK;Aluru, NR;Moore, J
离子水凝胶广泛应用于微流体流动的控制、肌肉样致动器的开发、过滤/分离和药物输送等许多应用，这使得正确理解这些材料变得非常重要。从水凝胶与许多生物组织相似的角度来看，理解水凝胶的性质也很重要。通常，凝胶大小对外部溶液pH值和盐浓度敏感。在本文中，我们开发了模型来预测水凝胶在缓冲pH溶液中的溶胀/溶胀。建立了一个平衡模型来预测在给定pH值和溶液中盐浓度下水凝胶的溶胀程度。建立了一个动力学模型来预测溶液pH变化时水凝胶的溶胀速率。实验表征了水凝胶在不同pH溶液中的力学性能。通过实验研究了水凝胶的溶胀程度和溶胀速率。将模拟结果与实验结果进行了比较，发现所建立的模型能够准确地预测溶胀/溶胀过程。然后使用验证的模型来研究各种水凝胶和溶液参数对水凝胶溶胀/溶胀程度和速率的影响。
The widespread application of ionic hydrogels in a number of applications like control of microfluidic flow, development of muscle-like actuators, filtration/separation and drug delivery makes it important to properly understand these materials. Understanding hydrogel properties is also important from the standpoint of their similarity to many biological tissues. Typically, gel size is sensitive to outer solution pH and salt concentration. In this paper, we develop models to predict the swelling/deswelling of hydrogels in buffered pH solutions. An equilibrium model has been developed to predict the degree of swelling of the hydrogel at a given pH and salt concentration in the solution. A kinetic model has been developed to predict the rate of swelling of the hydrogel when the solution pH is changed. Experiments are performed to characterize the mechanical properties of the hydrogel in different pH solutions. The degree of swelling as well as the rate of swelling of the hydrogel are also studied through experiments. The simulations are compared with experimental results and the models are found to predict the swelling/deswelling processes accurately. The validated models are then used to study the influence of the various hydrogel and solution parameters on the degree and rate of swelling/deswelling of the hydrogel.