The role of lactic acid in muscle contraction
The role of lactic acid in muscle contraction
复制标题
乳酸在肌肉收缩中的作用
DOI：
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复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Takashi Yamada
中科院分区：
文献类型：
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作者：
M. Wada;T. Mishima;Takashi Yamada
反复剧烈的骨骼肌收缩导致力量产生能力的逐渐丧失。这种功能下降通常被称为肌肉疲劳。自从弗莱彻和霍普金斯（1907）的工作以来，人们已经知道疲劳的肌肉会积累乳酸。乳酸积累引起的细胞内酸中毒被认为是导致剧烈运动疲劳的最重要原因。然而，最近对传统观点的挑战表明，乳酸在肌肉收缩中的作用与早期研究所暗示的不同。这篇简短的综述介绍了（1）我们对乳酸的认识的简短历史，解释了乳酸和疲劳之间因果关系的早期接受，（2）证据表明酸中毒引起的变化的温度依赖性和酸中毒的有益作用，（3）乳酸产生延缓，而不是引起酸中毒的建议。这些发现要求我们重新评估我们对乳酸、酸中毒和肌肉疲劳的概念。
Repeated intense skeletal muscle contraction leads to a progressive loss of force-generating capacity. This decline in function is generally referred to as muscular fatigue. Since the work of Fletcher and Hopkins (1907), it has been known that fatigued muscles accumulate lactic acid. Intracellular acidosis due to lactic acid accumulation has been regarded as the most important cause of fatigue during intense exercise. Recent challenges to the traditional view, however, have suggested that lactic acid plays a role in muscle contraction distinct from that implied by earlier studies. This brief review presents (1) a short history of our understanding about lactic acid that explains the early acceptance of a causal relationship between lactic acid and fatigue, (2) evidence to show the temperature dependence of acidosis-induced changes and the beneficial effect of acidosis, and (3) a proposal that lactate production retards, not causes, acidosis. These findings require us to reevaluate our notions of lactic acid, acidosis and muscular fatigue.
影响因子：
5.5
作者：
PATE, E;BHIMANI, M;COOKE, R
通讯作者：
COOKE, R
酸性pH值对兔骨骼肌丝ATP酶活性和肌钙蛋白Ca2+结合的影响。
DOI：
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发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Blanchard,EM;Pan,BS;Solaro,RJ
通讯作者：
Solaro,RJ
银离子通过作用于肌浆网的明显生理释放位点触发 Ca2 释放。
DOI：
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发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Salama,G;Abramson,J
通讯作者：
Abramson,J