Thoughts on Obesity and Brain Glucose
Thoughts on Obesity and Brain Glucose
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DOI：
10.1016/j.cell.2016.04.057
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发表时间：
2016-05
期刊：
影响因子：
64.5
通讯作者：
M. Heneka;P. Nicotera
中科院分区：
文献类型：
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作者：
M. Heneka;P. Nicotera
大脑代谢的稳态控制对神经元活动至关重要。Jais等人（2016）报道，高脂肪饮食引起的脑葡萄糖摄取减少通过外周、产生vegf的巨噬细胞向血脑屏障募集来自我纠正。他们的研究结果进一步表明，恢复大脑葡萄糖供应可能有助于防止阿尔茨海默病的认知障碍。
Homeostatic control of brain metabolism is essential for neuronal activity. Jais et al., (2016) report that reduced brain glucose uptake elicited by a high-fat diet self-corrects by the recruitment of peripheral, VEGF-producing macrophages to the blood-brain barrier. Their findings further suggest that restoring brain glucose availability might help protect from cognitive impairment in Alzheimer's disease.