Quantifying cortical development in typically developing toddlers and young children, 1-6 years of age.
Quantifying cortical development in typically developing toddlers and young children, 1-6 years of age.
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DOI：
10.1016/j.neuroimage.2017.04.010
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发表时间：
2017-06
期刊：
影响因子：
5.7
通讯作者：
Deoni SCL
中科院分区：
文献类型：
--
作者：
Remer J;Croteau-Chonka E;Dean DC 3rd;D'Arpino S;Dirks H;Whiley D;Deoni SCL
皮质成熟，包括厚度、体积、表面积和折叠（脑回化）的年龄相关变化，在发育脑功能和可塑性中发挥核心作用。此外，异常皮质成熟是各种行为，智力和精神疾病的可疑基质。然而，为了表征与这些疾病相关的改变的发展，1至6岁之间的神经型儿童的皮质发育的规范模式的赞赏，在此期间出现许多行为和发育障碍的大脑发育高峰期，是必要的。为此，我们检查了一组140名健康儿童的34个双侧区域的皮质厚度，表面积，平均曲率和灰质体积，这些儿童没有异常发育的主要危险因素。从这些数据中，我们观察到线性，对数和二次模式的变化与年龄取决于大脑区域。在大脑的大部分区域观察到皮质变薄，范围为10%至20%，但后脑结构除外，其显示1至5年的初始皮质变薄，随后变厚。在研究的年龄范围内，皮质表面积扩张范围为20%至108%，皮质曲率变化为1-20%。对于4个皮质测量中的每一个，在整个发育过程中观察到左右半球不对称。我们的研究结果提出了新的见解，在一个重要的，但在研究的发展窗口的皮质发育的规范模式，并提供了一个有价值的参考，在神经发育障碍中观察到的轨迹可以比较。分析皮质厚度、表面积、曲率和灰质体积。婴儿和儿童皮质成熟的区域特异性轨迹。早期大脑发育过程中的显著不对称性分析。基于性别的大脑发育差异。
Cortical maturation, including age-related changes in thickness, volume, surface area, and folding (gyrification), play a central role in developing brain function and plasticity. Further, abnormal cortical maturation is a suspected substrate in various behavioral, intellectual, and psychiatric disorders. However, in order to characterize the altered development associated with these disorders, appreciation of the normative patterns of cortical development in neurotypical children between 1 and 6 years of age, a period of peak brain development during which many behavioral and developmental disorders emerge, is necessary. To this end, we examined measures of cortical thickness, surface area, mean curvature, and gray matter volume across 34 bilateral regions in a cohort of 140 healthy children devoid of major risk factors for abnormal development. From these data, we observed linear, logarithmic, and quadratic patterns of change with age depending on brain region. Cortical thinning, ranging from 10% to 20%, was observed throughout most of the brain, with the exception of posterior brain structures, which showed initial cortical thinning from 1 to 5 years, followed by thickening. Cortical surface area expansion ranged from 20% to 108%, and cortical curvature varied by 1–20% across the investigated age range. Right-left hemisphere asymmetry was observed across development for each of the 4 cortical measures. Our results present new insight into the normative patterns of cortical development across an important but under studied developmental window, and provide a valuable reference to which trajectories observed in neurodevelopmental disorders may be compared. Analysis of cortical thickness, surface area, curvature, and gray matter volume. Region specific trajectories of cortical maturation in infants and children. Analysis of significant asymmetry during early brain development. Differential brain development based on sex.