Preparation, fractionation, and structure of block copolymers polystyrene-poly(carbobenzoxy-L-lysine) and polybutadiene-poly(carbobenzoxy-L-lysine)
Preparation, fractionation, and structure of block copolymers polystyrene-poly(carbobenzoxy-L-lysine) and polybutadiene-poly(carbobenzoxy-L-lysine)
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DOI：
10.1002/macp.1977.021780604
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发表时间：
1977-06
影响因子：
2.5
通讯作者：
J. Billot;A. Douy;B. Gallot
中科院分区：
文献类型：
--
作者：
J. Billot;A. Douy;B. Gallot
采用阴离子聚合法合成聚乙烯基嵌段（聚苯乙烯或聚丁二烯）和多肽嵌段（聚苄氧羰基-L-赖氨酸）的AB嵌段共聚物，然后将其活性端转化为伯胺官能团，作为大分子引发剂引发α-氨基酸的N-羧酸酐（NCA）聚合。分馏后，通过红外光谱和X-射线衍射的研究表明，共聚物在二氧六环溶液中和干燥状态下表现出层状结构。在这种层状结构中，多肽链以α-螺旋构象存在，以六边形阵列排列并折叠。
AB block copolymers with a polyvinyl block (polystyrene or polybutadiene) and a polypeptide block (poly(carbobenzoxy-L-lysine)) were prepared by the following method: at first the polyvinyl block was synthesized by anionic polymerization, then its living end was transformed into a primary amine function and it was used as a macromolecular initiator for the polymerization of the N-carboxy anhydride (NCA) of an α-amino acid. After fractionation, studies of the copolymers by IR spectroscopy and X-ray diffraction showed, that they exhibit a lamellar structure in dioxane solution and in the dry state. In this lamellar structure the polypeptide chains, present in an α-helix conformation, are arranged in an hexagonal array and are folded.