A MYC target long non-coding RNA GATA2-AS1 regulates non-small cell lung cancer growth
A MYC target long non-coding RNA GATA2-AS1 regulates non-small cell lung cancer growth
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DOI：
10.4149/neo_2019_190210n112
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发表时间：
2019-01-01
期刊：
影响因子：
3
通讯作者：
Sun, G. Y.
中科院分区：
文献类型：
--
作者：
Zhang, L.;Gao, L.;Sun, G. Y.
非小细胞肺癌（NSCLC）是组织学上最常见的肺癌亚型，近年来越来越多的证据表明长链非编码rna （lncRNAs）参与了肿瘤的发生。在这里，我们发现一种长链非编码RNA GATA2- as1通过调节GATA2抑制非小细胞肺癌细胞的增殖。GATA2- as1基因位于染色体上GATA2的反义链上，GATA2- as1 RNA在GATA2的启动子区与GATA1蛋白相互作用，抑制其转录。此外，在NSCLC细胞中，MYC可抑制GATA2-AS1的转录。总之，我们的研究发现了lncRNA GATA2-AS1在人类非小细胞肺癌生长中的作用，从而为肺癌药物提供了一个潜在的靶点。
Non-small cell lung cancer (NSCLC) is the most prevalent subtype of lung cancer histologically, and an increasing number of evidences have shown during the past years that long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Here we found a long non-coding RNA, GATA2-AS1, repressing NSCLC cells proliferation via regulating GATA2. GATA2-AS1 gene is located at antisense strand of GATA2 on chromosome while GATA2-AS1 RNA interacts with GATA1 protein at promoter region of GATA2 and then inhibits its transcription. Moreover, GATA2-AS1 is transcriptionally repressed by MYC in NSCLC cells. To conclude, our study discovered the role of lncRNA GATA2-AS1 in human non-small cell lung cancer growth thus providing a potential target for lung cancer drugs.