The ETV6, CDKN1B and D12S178 loci are involved in a segment commonly deleted in various 12p aberration in different hematological malignancies.
The ETV6, CDKN1B and D12S178 loci are involved in a segment commonly deleted in various 12p aberration in different hematological malignancies.
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ETV6、CDKN1B 和 D12S178 基因座涉及不同血液恶性肿瘤中各种 12p 畸变中通常缺失的片段。
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
H. van den Berghe
中科院分区：
文献类型：
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作者：
I. Wlodarska;P. Marynen;R. la Starza;C. Mecucci;H. van den Berghe
包括12号染色体短臂缺失在内的结构重排是各种血液学恶性疾病中常见的细胞遗传学发现。使用FISH和一组DNA探针，我们在22例不同血液病患者中检测到12p共同区域的缺失。其中9例的细胞遗传学特征为一个缺失（12p）， 7例为不平衡易位，其余的12p区域的缺失被易位和插入所掩盖，在12号染色体的短臂上增加了额外的物质。在所分析的所有病例中发现的最小的常见缺失区域包括ETV6， p27kipl （CDKN1B）基因和D12S178标记。
Structural rearrangements including deletions of the short arm of chromosome 12 are frequent cytogenetic findings in various hematologic malignant disorders. Using FISH with a panel of DNA probes we detected loss of a common region of 12p in 22 patients with different hematologic disorders. Nine of them were characterized cytogenetically by a del(12p), seven by unbalanced translocations, and in the remaining cases the loss of the 12p region was masked by translocations and insertions, adding extra material to the short arm of chromosome 12. The smallest commonly deleted region found in all cases analyzed included ETV6, the gene for p27kipl (CDKN1B), and the D12S178 marker.