Threat-induced anxiety during goal pursuit disrupts amygdala-prefrontal cortex connectivity in posttraumatic stress disorder.
Threat-induced anxiety during goal pursuit disrupts amygdala-prefrontal cortex connectivity in posttraumatic stress disorder.
复制标题
在创伤后应激障碍中，目标追求过程中威胁引起的焦虑会破坏杏仁核-前额皮质的连接。
DOI：
10.1038/s41398-020-0739-4
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发表时间：
2020
影响因子：
6.8
通讯作者：
Morey,RajendraA
中科院分区：
文献类型：
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作者：
Sun,Delin;Gold,AndreaL;Swanson,ChelseaA;Haswell,CourtneyC;Brown,VanessaM;Stjepanovic,Daniel;VAMid-AtlanticMIRECCWorkgroup;LaBar,KevinS;Morey,RajendraA
为了研究目标追求过程中不可预测的威胁如何影响创伤后应激障碍（PTSD）的额叶边缘系统活动和功能连接，我们比较了创伤后应激障碍（PTSD）退伍军人（n= 25）与创伤暴露对照组（n= 25）。参与者进行功能性磁共振成像（fMRI），同时参与计算机化的追逐和捕获游戏任务，包括优化捕获虚拟猎物获得的金钱奖励，同时避免被虚拟捕食者捕获。这个游戏是在两个交替的环境下进行的，一个是暴露在不可预测的任务无关的威胁下，来自随机发生的电击，另一个是非威胁控制条件。激活和杏仁核和腹内侧前额叶皮层（vmPFC）之间的功能连接进行了测试，在威胁和非威胁任务的情况下，广义心理生理相互作用（gPPI）分析。PTSD患者在不同背景下的焦虑程度高于对照组。较好的任务表现，成功地避免捕获的捕食者的威胁相比，非威胁的情况下，与更强的左杏仁核-VMPFC功能连接的控制和更大的VMPFC激活PTSD患者。创伤后应激障碍症状的严重程度呈负相关，与VMPFC激活的创伤暴露的控制和右杏仁核-VMPFC功能连接在所有参与者的威胁相对于非威胁的情况下。研究结果表明，患有PTSD的退伍军人在目标导向行为的威胁调制下破坏了杏仁核-vmPFC功能连接和更大的局部vmPFC处理，特别是与成功避免金钱奖励损失有关。相比之下，没有PTSD的创伤幸存者在目标导向行为中依赖于更强的威胁调制的左杏仁核-VMPFC功能连接，这可能代表了与服从相关的功能适应。
To investigate how unpredictable threat during goal pursuit impacts fronto-limbic activity and functional connectivity in posttraumatic stress disorder (PTSD), we compared military veterans with PTSD (n= 25) vs. trauma-exposed control (n= 25). Participants underwent functional magnetic resonance imaging (fMRI) while engaged in a computerized chase-and-capture game task that involved optimizing monetary rewards obtained from capturing virtual prey while simultaneously avoiding capture by virtual predators. The game was played under two alternating contexts—one involving exposure to unpredictable task-irrelevant threat from randomly occurring electrical shocks, and a nonthreat control condition. Activation in and functional connectivity between the amygdala and ventromedial prefrontal cortex (vmPFC) was tested across threat and nonthreat task contexts with generalized psychophysiological interaction (gPPI) analyses. PTSD patients reported higher anxiety than controls across contexts. Better task performance represented by successfully avoiding capture by predators under threat compared with nonthreat contexts was associated with stronger left amygdala–vmPFC functional connectivity in controls and greater vmPFC activation in PTSD patients. PTSD symptom severity was negatively correlated with vmPFC activation in trauma-exposed controls and with right amygdala–vmPFC functional connectivity across all participants in the threat relative to nonthreat contexts. The findings showed that veterans with PTSD have disrupted amygdala–vmPFC functional connectivity and greater localized vmPFC processing under threat modulation of goal-directed behavior, specifically related to successfully avoiding loss of monetary rewards. In contrast, trauma survivors without PTSD relied on stronger threat-modulated left amygdala–vmPFC functional connectivity during goal-directed behavior, which may represent a resilience-related functional adaptation.