Role of RNA structure in regulating pre-mRNA splicing.
Role of RNA structure in regulating pre-mRNA splicing.
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DOI：
10.1016/j.tibs.2009.10.004
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发表时间：
2010-03
影响因子：
13.8
通讯作者：
Berglund, J. Andrew
中科院分区：
文献类型：
--
作者：
Warf, M. Bryan;Berglund, J. Andrew
Pre-mRNA剪接是从RNA转录本中去除非编码内含子的过程，由剪接体和其他辅助因子共同完成。一般来说，对剪接的研究主要集中在pre-mRNA内的序列上，而没有考虑到这些序列可能形成的结构。然而，我们认为在考虑剪接机制时，RNA结构的作用值得更多的考虑。RNA结构可以抑制或辅助剪接体成分与前体mrna的结合，或者通过将重要序列靠近来提高剪接效率。最近的报道还发现了可以通过调节RNA结构来调节剪接的蛋白质和小分子，从而扩大了我们对用于调节剪接的机制的了解。
Pre-mRNA splicing is the process of removing non-coding introns from RNA transcripts and is carried out by the spliceosome, along with other auxiliary factors. In general, research in splicing has focused on the sequences within the pre-mRNA, without taking into account the structures that these sequences might form. However, we propose that the role of RNA structure deserves more consideration when thinking about splicing mechanisms. RNA structures can inhibit or aid binding of spliceosomal components to the pre-mRNA, or can increase splicing efficiency by bringing important sequences into close proximity. Recent reports have also identified proteins and small molecules that can regulate splicing by modulating RNA structures, thus expanding our knowledge of the mechanisms used to regulate splicing.
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影响因子：
2.9
作者：
Coleman, TP;Roesser, JR
通讯作者：
Roesser, JR
影响因子：
56.9
作者：
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影响因子：
5.3
作者：
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DOI：
10.1073/pnas.1932834100
发表时间：
2003-09-30
影响因子：
11.1
作者：
Chen, Y;Stephan, W
通讯作者：
Stephan, W
影响因子：
5.3
作者：
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通讯作者：
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