Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice.
Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice.
复制标题
环己基-灰塞利霉素对小鼠中的结核分枝杆菌有活性。
DOI：
10.1128/aac.01400-21
复制
发表时间：
2022-01-18
影响因子：
4.9
通讯作者：
Dick T
中科院分区：
文献类型：
--
作者：
Aragaw WW;Roubert C;Fontaine E;Lagrange S;Zimmerman MD;Dartois V;Gengenbacher M;Dick T
环己基-灰霉素是用于抗结核（TB）的临床前候选物。在这里，我们表明，这种口服cyclodepsipeptide在体外和小鼠感染模型中也对固有耐药的非结核分枝杆菌Mycobacterium dumessus具有活性。这为M.支持筛选结核病药物发现工作中产生的化学物质的战略，以快速发现针对M.你好
Cyclohexyl-griselimycin is a preclinical candidate for use against tuberculosis (TB). Here, we show that this oral cyclodepsipeptide is also active against the intrinsically drug-resistant nontuberculous mycobacterium Mycobacterium abscessus in vitro and in a mouse model of infection. This adds a novel advanced lead compound to the M. abscessus drug pipeline and supports a strategy of screening chemical matter generated in TB drug discovery efforts to fast-track the discovery of novel antibiotics against M. abscessus.