Environmental Candida auris and the Global Warming Emergence Hypothesis.
Environmental Candida auris and the Global Warming Emergence Hypothesis.
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DOI：
10.1128/mbio.00360-21
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发表时间：
2021-03-16
期刊：
影响因子：
6.4
通讯作者：
Robert V
中科院分区：
文献类型：
--
作者：
Casadevall A;Kontoyiannis DP;Robert V
全球变暖被认为是不同大陆几乎同时出现作为医院病原体的耳念珠菌不同分支的一个原因。全球变暖出现假说认为，耳念珠菌在临床识别之前就存在于环境中，并且由于对气候变化的热适应而对人类产生致病性。从偏远的安达曼群岛的两个地点分离出耳念珠菌，使其成为一种环境生物，这是该假设的必要条件。全球变暖被认为是不同大陆几乎同时出现作为医院病原体的耳念珠菌不同分支的一个原因。全球变暖出现假说认为，耳念珠菌在临床识别之前就存在于环境中，并且由于对气候变化的热适应而对人类产生致病性。从偏远的安达曼群岛的两个地点分离出耳念珠菌，使其成为一种环境生物，这是该假设的必要条件。观察到一种环境分离株在哺乳动物温度下比临床菌株生长得慢，这与它们的祖先最近适应更高温度的观点是一致的。耳念珠菌可以从环境中回收的知识应该会促使更多的研究来确定其生态位，并且对未来环境分离物的分析将为验证或反驳全球变暖出现假说提供证据。
Global warming was proposed to be a contributing cause for the nearly simultaneous emergence of different clades of Candida auris as a nosocomial pathogen in different continents. The global warming emergence hypothesis posits that C. auris existed in the environment prior to its clinical recognition and became pathogenic for humans because of thermal adaptation in response to climate change. The isolation of C. auris from two sites in the remote Andaman Islands establishes it as an environmental organism, a necessary condition for the hypothesis. Global warming was proposed to be a contributing cause for the nearly simultaneous emergence of different clades of Candida auris as a nosocomial pathogen in different continents. The global warming emergence hypothesis posits that C. auris existed in the environment prior to its clinical recognition and became pathogenic for humans because of thermal adaptation in response to climate change. The isolation of C. auris from two sites in the remote Andaman Islands establishes it as an environmental organism, a necessary condition for the hypothesis. The observation that one environmental isolate grew slower at mammalian temperatures than clinical strains is consistent with the notion that their ancestor recently adapted to higher temperatures. The knowledge that C. auris can be recovered from the environment should prompt additional searches to define its ecological niches, and the analysis of future environmental isolates will provide evidence for validating or refuting the global warming emergence hypothesis.