Atropine for the Treatment of Childhood Myopia: Effect on Myopia Progression after Cessation of Atropine
Atropine for the Treatment of Childhood Myopia: Effect on Myopia Progression after Cessation of Atropine
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DOI：
10.1016/j.ophtha.2008.10.020
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发表时间：
2009-03-01
期刊：
影响因子：
13.7
通讯作者：
Chua, Wei-Han
中科院分区：
文献类型：
--
作者：
Tong, Louis;Huang, Xiao Ling;Chua, Wei-Han
目的：本研究的目的是评估停止局部阿托品治疗后近视进展的影响。设计：平行组、安慰剂对照、随机、双盲研究。参与者：400名6至12岁的儿童，他们的球面屈光不正相当于-1.00至-6.00屈光(D)，散光不超过-1.50 D。干预：未进行干预。受试者在停止治疗后随访12个月，其中包括1%阿托品或载体眼药水，每晚1次，持续2年。通过随机化，每位受试者只选择1只眼睛进行治疗。主要观察指标：主要疗效观察指标为单眼麻痹性自屈光测量的球等效屈光变化和超声测量的眼轴长度变化。结果：停止使用阿托品滴剂后，阿托品治疗组在1年内的平均进展为-1.14+/-0.80 D，而安慰剂治疗组的进展为-0.38+/-0.39 D (P
Purpose: The aim of this study was to assess the effect on myopia progression after cessation of topical atropine treatment.Design: Parallel-group, placebo-controlled, randomized, double-masked study.Participants: Four hundred children aged 6 to 12 years with refractive error of spherical equivalent -1.00 to -6.00 diopters (D) and astigmatism of -1.50 D or less.Intervention: No intervention was administered. Subjects were followed up for 12 months after stopping treatment, which consisted of either 1% atropine or vehicle eyedrops once nightly for 2 years. Only 1 eye of each subject was chosen through randomization for treatment.Main Outcome Measures: The main efficacy outcome measures were change in spherical equivalent refraction as measured by cycloplegic autorefraction and change in ocular axial length as measured by ultrasonography.Results: After cessation of atropine drops, the mean progression in the atropine-treated group was -1.14+/-0.80 D over 1 year, whereas the progression in placebo-treated eyes was -0.38+/-0.39 D (P