Movement-related coupling of human subthalamic nucleus spikes to cortical gamma
Movement-related coupling of human subthalamic nucleus spikes to cortical gamma
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DOI：
10.7554/elife.51956
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发表时间：
2020-03-11
期刊：
影响因子：
7.7
通讯作者：
Richardson, R. Mark
中科院分区：
文献类型：
--
作者：
Fischer, Petra;Lipski, Witold J.;Richardson, R. Mark
皮质-基底神经节相互作用不断塑造我们的运动方式。关于该电路如何工作的想法主要基于仅考虑发射率作为信息传输机制的模型。然而，伴随运动的神经活动的一个显着特征是运动皮质和基底神经节伽马同步性的增加。为了研究运动过程中基底神经节神经元放电与皮质伽玛活动之间的关系，我们分析了抓握过程中的人类 ECoG 和丘脑底核 (STN) 单位活动。我们发现，快速反应时间之前有增强的 STN 尖峰与皮质伽玛相耦合，表明在运动准备中的作用。重要的是，伽马相耦合的增加与平均 STN 放电率的变化无关，并且同侧与对侧运动的 STN 尖峰的相对时间偏移了半个伽马周期，这表明相对尖峰时间与放电率对于理解皮质基底节信息传递具有同样的相关性。
Cortico-basal ganglia interactions continuously shape the way we move. Ideas about how this circuit works are based largely on models those consider only firing rate as the mechanism of information transfer. A distinct feature of neural activity accompanying movement, however, is increased motor cortical and basal ganglia gamma synchrony. To investigate the relationship between neuronal firing in the basal ganglia and cortical gamma activity during movement, we analysed human ECoG and subthalamic nucleus (STN) unit activity during hand gripping. We found that fast reaction times were preceded by enhanced STN spike-to-cortical gamma phase coupling, indicating a role in motor preparation. Importantly, increased gamma phase coupling occurred independent of changes in mean STN firing rates, and the relative timing of STN spikes was offset by half a gamma cycle for ipsilateral vs. contralateral movements, indicating that relative spike timing is as relevant as firing rate for understanding cortico-basal ganglia information transfer.