Gamma interferon interferes with the negative regulation of macrophage activation by prostaglandin E2.
Gamma interferon interferes with the negative regulation of macrophage activation by prostaglandin E2.
复制标题
γ 干扰素干扰前列腺素 E2 对巨噬细胞活化的负调节。
DOI：
10.1016/0161-5890(84)90080-4
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发表时间：
1984
影响因子：
3.6
通讯作者：
Pace,JL
中科院分区：
文献类型：
--
作者：
Russell,SW;Pace,JL
小鼠巨噬细胞杀伤肿瘤细胞的活化受前列腺素E2（PGE2）负调控。这种激素的作用是关闭细胞溶解活性，这种活性是活化的结果。伴刀豆球蛋白A刺激的脾细胞的培养上清液中的淋巴因子已显示改变活化的巨噬细胞对PGE 2的负调节作用的敏感性，从而维持活化，如通过这些细胞持续表达肿瘤细胞杀伤所证明的。使用高度特异性的多克隆抗血清和γ干扰素产生的T细胞杂交瘤或重组DNA技术，我们在这里表明，一个淋巴因子负责介导的维护效果是γ干扰素。
Activation of mouse macrophages for tumor cell killing is negatively regulated by prostaglandin E2(PGE2). The effect of this hormone is to shut off cytolytic activity that is expressed as a consequence of activation. A lymphokine in the culture supernates of concanavalin A stimulated spleen cells has been shown to change the sensitivity of activated macrophages to the negative regulatory effects of PGE2, thereby maintaining activation, as manifested by the continued expression of tumor cell killing by these cells. Using a highly specific polyclonal antiserum and gamma interferon produced either by a T-cell hybridoma or by recombinant DNA technology we show here that one lymphokine responsible for mediating the maintenance effect is gamma interferon.