Carnosic acid: A potent chemopreventive agent against oral carcinogenesis
Carnosic acid: A potent chemopreventive agent against oral carcinogenesis
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DOI：
10.1016/j.cbi.2010.08.009
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发表时间：
2010-12-05
影响因子：
5.1
通讯作者：
Kumar, Veerasamy Vinoth
中科院分区：
文献类型：
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作者：
Manoharan, Shanmugam;VasanthaSelvan, MuthamizhSelvan;Kumar, Veerasamy Vinoth
本研究旨在探讨鼠尾草酸对 7,12-二甲基苯并蒽 (DMBA) 诱导的仓鼠颊囊癌的化学预防潜力。通过分析肿瘤发生率、肿瘤体积和负荷以及测量脂质过氧化、非酶和酶抗氧化剂以及 I 期和 II 期解毒酶的状态来评估化学预防潜力。通过在金色叙利亚仓鼠的颊囊中每周涂敷 3 次含 0.5% DMBA 的液体石蜡，持续 14 周，形成口腔鳞状细胞癌。在本研究中，仅用 DMBA 治疗的仓鼠中观察到 100% 肿瘤形成。此外，在 DMBA 诱导口腔癌发生过程中，脂质过氧化、抗氧化剂和 II 相解毒酶的状态发生显着改变。给DMBA治疗的动物口服鼠尾草酸，剂量为10毫克/公斤体重/天，完全阻止了仓鼠颊囊中肿瘤的形成。此外，鼠尾草酸发挥有效的抗脂质过氧化功能，并在 DMBA 诱导的仓鼠颊囊癌发生过程中刺激解毒级联反应。本研究的结果表明，鼠尾草酸的化学预防潜力可能是由于其抗脂质过氧化潜力以及在 DMBA 诱导的口腔癌发生过程中对致癌物解毒酶的调节作用。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
The present study was aimed to investigate the chemopreventive potential of carnosic acid in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. The chemopreventive potential was assessed by analyzing the tumor incidence, tumor volume and burden as well as by measuring the status of lipid peroxidation, non-enzymatic and enzymatic antioxidants and phase I and phase II detoxification enzymes. Oral squamous cell carcinoma was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. In the present study, 100% tumor formation was observed in hamsters treated with DMBA alone. Also, the status of lipid peroxidation, antioxidants and phase land phase II detoxification enzymes were significantly altered during DMBA-inducecl oral carcinogenesis. Oral administration of carnosic acid at a dose of 10 mg/kg body weight/day to DMBA-treated animals completely prevented the tumor formation in the hamsters' buccal pouches. Also, carnosic acid exerted potent anti-lipid peroxidative function and stimulated the detoxification cascade during DMBA-induced hamster buccal pouch carcinogenesis. The results of the present study suggest that the chemopreventive potential of carnosic acid is probably due to its anti-lipid peroxidative potential and modulating effect on carcinogen detoxification enzymes during DMBA-induced oral carcinogenesis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.