Induced pluripotent stem cells in cardiovascular drug discovery.
Induced pluripotent stem cells in cardiovascular drug discovery.
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DOI：
10.1161/circresaha.111.250266
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发表时间：
2013-02-01
影响因子：
20.1
通讯作者：
Willems E
中科院分区：
文献类型：
--
作者：
Mercola M;Colas A;Willems E
体细胞可以被重编程为多能状态，从而产生诱导多能干细胞（iPSC），这一意外发现使得产生表现出遗传特征和疾病的心血管细胞成为可能。在高通量分析中使用这些细胞应该拓宽我们对基本疾病机制的见解，并为患者提供许多益处，包括新的治疗方法和个性化治疗。在这里，我们回顾了最近在生成基于iPSC的心血管疾病模型及其在药物开发中的多种应用方面的进展。
The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state yielding induced pluripotent stem cells (iPSCs) has made it possible to produce cardiovascular cells exhibiting inherited traits and disorders. Use of these cells in high throughput analyses should broaden our insight into fundamental disease mechanisms and provide many benefits for patients, including new therapeutics and individually tailored therapies. Here we review recent progress in generating iPSC-based models of cardiovascular disease and their multiple applications in drug development.