Double minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review.
Double minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review.
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DOI：
10.1007/bf02717000
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发表时间：
2005-12-01
期刊：
影响因子：
--
通讯作者：
Gebhart, Erich
中科院分区：
文献类型：
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作者：
Gebhart, Erich
双分钟是几兆碱基对大小的微小球形染色质体，偶尔在造血系统肿瘤中发现，或多或少在人类实体瘤中发现。它们与存在的恶性肿瘤的较差预后和不良结果有关。随着分子细胞遗传学时代的开始，它们可以被定义为扩增 DNA 序列的细胞遗传学等价物。所涉及的染色体片段及其分子性质的鉴定导致了分子遗传学技术的发展，用于快速可靠地检测人类肿瘤中具有预后意义的重要癌基因扩增，从而实现基因靶向治疗。
Double minutes are tiny spherical chromatin bodies of a few mega-base pairs of size which are found occasionally in hematopoietic neoplasia and more or less often in human solid tumors. They have been associated with worse prognosis and poor outcome of the malignancies where present. With the beginning era of molecular cytogenetics they could be defined as cytogenetic equivalents of amplified DNA sequences. The identification of involved chromosomal segments and their molecular nature led to the development of molecular genetic techniques for a rapid and reliable detection of prognostically important oncogene amplifications in human tumors and,as a consequence, to gene-targeted therapy.