Does umbilical cord blood polymerase chain reaction positivity indicate in utero (pre-labor) HIV infection?
Does umbilical cord blood polymerase chain reaction positivity indicate in utero (pre-labor) HIV infection?
复制标题
脐带血聚合酶链反应阳性是否表明子宫内（临产前）感染艾滋病毒？
DOI：
10.1097/00002030-199711000-00012
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Miotti,PG
中科院分区：
文献类型：
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作者：
Biggar,RJ;Mtimavalye,L;Justesen,A;Broadhead,R;Miley,W;Waters,D;Goedert,JJ;Chiphangwi,JD;Taha,TE;Miotti,PG
目的：比较脐带血HIVDNA阳性婴儿与脐带血HIVDNA阴性婴儿早期感染HIVDNA的危险因素。方法：1994年在马拉维布兰太尔进行了一项研究。对脐带血阳性婴儿和脐带血阴性/HIV阳性婴儿的出生体重和传播危险因素在出生后(4-7周龄)进行比较。结果：在249例HIV感染者中，83例(33%)脐带血阳性，166例脐带血阴性。脐带血阳性婴儿的平均出生体重比最初脐带血阴性婴儿轻2.1%(59克)；最初脐带血阴性婴儿比艾滋病毒感染母亲所生的未感染婴儿轻2.8%(80克)。脐带血HIV感染阳性和阴性婴儿感染的危险因素无显著差异；当传播增加时，HIV感染脐带血阳性和阴性婴儿的感染比例增加的比例相似。解释：脐带血HIV DNA阳性并不能识别宫内HIV感染的婴儿亚群，提示HIV感染脐带血阳性和阴性婴儿感染HIV的时间和途径相似。
Objective:To compare risk factors for infants whose cord blood was positive for HIV DNA with those who were cord blood-negative but found to be HIV DNA-positive in early infancy.Methods:In 1994, infants born to HIV-infected women were enrolled in a study in Blantyre, Malawi. Birth weight and transmission risk factors from cord blood-positive infants were compared with cord blood-negative/HIV-positive infants on their first postnatal visit (4-7 weeks of age). Testing for HIV DNA on cord and peripheral blood was performed by polymerase chain reaction.Results:Of 249 HIV-infected infants (overall transmission rate, 26%), 83 (33%) were cord blood-positive and 166 were initially cord blood-negative. The mean birth weight was 2.1%(59 g) lighter in cord blood-positive infants than initially cord blood-negative infants; initially cord blood-negative infants were 2.8%(80 g) lighter than uninfected infants born to HIV-infected women. There were no significant differences in the risk factors for infection between HIV-infected cord blood-positive and-negative infants; when transmission was increased, both HIV-infected cord blood-positive and-negative infants contributed to the increase in a similar proportion.Interpretation:It was concluded that umbilical cord blood positivity for HIV DNA did not identify a subset of in utero HIV-infected infants and suggested that HIV-infected cord blood-positive and-negative infants have similar timing and routes of HIV infection.