Disposition of roxithromycin in the epididymis after repeated oral administration.
Disposition of roxithromycin in the epididymis after repeated oral administration.
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重复口服后罗红霉素在附睾中的分布。
DOI：
10.1093/jac/30.2.197
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Françoise Bressolle
中科院分区：
文献类型：
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作者：
Pierre Costa;Francois Desclaux d'Arramon;Anne Gouby;Henri Navratil;F. Gény;M. Galtier;Françoise Bressolle
为了评价罗红霉素在附睾炎治疗中的作用，对罗红霉素进行了附睾部经皮渗透试验。17例因前列腺瘤或前列腺癌而入院接受手术的患者，先口服罗红霉素150 mg，每日2次，连服3d，然后于术前(手术切开前3h)口服150 mg。采用微生物法测定血清和附睾罗红霉素浓度。左侧和右侧附睾液平均浓度分别为6.48±4.88和5.98±3.92 mg/kg，组织/血清比值分别为0.88±-0.57和0.84+/-0.53。罗红霉素在血清和组织中的浓度在受试者之间存在很大的差异，这在其他大环内酯类抗生素中很常见。本研究中观察到的沙眼衣原体(0.25~1 mg/L)和解脲支原体(0.5 mg/L)在血清和组织中的浓度均高于MIC90。
The epididymal penetration of roxithromycin was studied in order to evaluate the drug for use in the treatment of epididymo-orchitis. Seventeen patients hospitalized for surgery as part of treatment for prostatic adenoma or prostatic cancer were premedicated orally with roxithromycin 150 mg bd for three days followed by 150 mg pre-operatively (3 h before surgical incision). Roxithromycin concentrations in serum and epididymis were determined by microbiological assay. The mean epididymal concentrations were 6.48 +/- 4.88 and 5.98 +/- 3.92 mg/kg for left and right epididymis respectively and the corresponding mean tissue/serum ratios 0.88 +/- 0.57 and 0.84 +/- 0.53. The wide intersubject variation in the concentration of roxithromycin found in serum and tissue is commonly seen with other macrolide antibiotics. The concentrations observed in this study in serum and tissue were greater than the MIC90s for Chlamydia trachomatis (0.25 to 1 mg/L), and Ureaplasma urealyticum (0.5 mg/L).