Testis-/embryo-expressed genes are clustered in the mouse H-2K region.
Testis-/embryo-expressed genes are clustered in the mouse H-2K region.
复制标题
睾丸/胚胎表达的基因聚集在小鼠 H-2K 区域。
DOI：
10.1073/pnas.89.2.773
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发表时间：
1992
影响因子：
11.1
通讯作者：
Artzt,K
中科院分区：
文献类型：
--
作者：
Yeom,YI;Abe,K;Bennett,D;Artzt,K
小鼠的主要组织相容性复合体（MHC）位于17号染色体上的t复合体的远端倒位。除了在免疫反应中起主要作用的基因外，它还包含多种基因。在人类中，已知许多疾病与MHC基因座相关。此外，至少有三个隐性胚胎t-致死突变已映射到MHC。在这里，分子遗传学方法被用来研究详细的基因组结构的240个酶（kb）周围的H-2K基因和150 kb的部分同源区域位于远端倒位的t复合物。结合先前的发现，发现H-2K区域包含令人印象深刻的高密度基因-在240 kb中有12个转录单位。令人惊讶的是，几乎所有这些基因都在睾丸和/或胚胎中表达。该区域的基因组组织与只有三个基因和内源性逆转录病毒存在的150 kb同源区域形成对比。
The major histocompatibility complex (MHC) of the mouse is located on chromosome 17 in the distal inversion of the t complex. In addition to genes playing major roles in the immune response, it contains a diversity of genes. In humans, numerous diseases are known to be associated with the MHC loci. Moreover, at least three recessive embryonic t-lethal mutations have been mapped to the MHC. Here a molecular genetic approach was used to study the detailed genomic structure of 240 kilobases (kb) surrounding the H-2K gene and 150 kb of a partly homologous region located in the distal inversion of the t complex. Combined with previous findings, the H-2K region was found to contain an impressively high density of genes--12 transcription units in 240 kb. Surprisingly, virtually all of these genes are expressed in testis and/or embryos. The genomic organization of this region is contrasted with the 150 kb of the homologous area where only three genes and an endogenous retrovirus reside.