MOLECULAR-CLONING AND EXPRESSION OF CARCINOEMBRYONIC ANTIGEN GENE FAMILY MEMBERS
MOLECULAR-CLONING AND EXPRESSION OF CARCINOEMBRYONIC ANTIGEN GENE FAMILY MEMBERS
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DOI：
10.1159/000217923
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发表时间：
1995-01-01
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影响因子：
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通讯作者：
THOMPSON, JA
中科院分区：
文献类型：
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作者：
THOMPSON, JA
癌胚抗原(CEB)基因家族由大约30个基因组成，其中17个基因具有转录活性。这些基因紧密聚集在19号染色体的长臂上。有两个主要亚群可区分，一个编码CEA及其经典的非特异性交叉反应抗原(NCA)，第二个编码妊娠特异性糖蛋白(PSGs)。CEA家族属于免疫球蛋白超家族。CEA亚群成员要么是通过糖基磷脂酰肌醇锚点结合的膜，要么是完整的膜蛋白，而PSC分子是从细胞分泌的。尽管有很高的序列相似性，但CEA家族成员表现出不同的表达模式，表明不同的功能。除了在各种腺癌中高表达外，CEA还存在于胃肠道衬里上皮、汗腺、肺上皮和睾丸中。NCA通常与CEA共表达，但也存在于粒细胞中。PSGs在胎盘、颌下腺和胎肝的合体滋养层细胞以及绒毛膜癌和乳腺癌中共同表达。
The carcinoembryonic antigen (CEB) gene family consists of approximately 30 genes, of which 17 are transcriptionally active. These genes are tightly clustered on the long arm of chromosome 19. Two main subgroups are distinguishable, one encoding CEA and its classical non-specific cross-reacting antigens (NCAs) and the second encoding the pregnancy-specific glycoproteins (PSGs). The CEA family belongs to the immunoglobulin superfamily. CEA subgroup members are either membrane bound through a glycosyl phosphatidylinositol anchor, or are integral membrane proteins, whereas PSC molecules are secreted from the cell. Despite high sequence similarity, CEA family members reveal variable expression patterns, indicating different functions. Apart from its high expression in various adenocarcinomas, CEA is found in epithelia lining the gastrointestinal tract, in eccrine sweat glands, lung epithelia and testes. The NCAs are often coexpressed with CEA, but are also found in granulocytes. PSGs are coexpressed in syncytiotrophoblast cells of the placenta, submandibular salivary glands and fetal liver, as well as in choriocarcinomas and breast tumours.