Prenatal Famine Exposure and Long-Term Consequences for Anthropometry and Adult Health
Prenatal Famine Exposure and Long-Term Consequences for Anthropometry and Adult Health
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DOI：
10.1007/978-1-4419-1788-1_61
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
T. Roseboom;R. Painter;S. Rooij
中科院分区：
文献类型：
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作者：
T. Roseboom;R. Painter;S. Rooij
这篇论文描述了一项对2414名在荷兰饥荒期间出生的人进行的队列研究的结果。我们发现，在妊娠早期遭受饥荒的人群中，冠心病发病率、致动脉粥样硬化的脂质谱、凝血功能紊乱以及应激反应增加。在怀孕早期遭受饥荒的妇女更肥胖，患乳腺癌的风险也更高。在妊娠中期遭受饥荒的人有更多的微量蛋白尿和阻塞性气道疾病。在妊娠任何阶段暴露于饥荒都与葡萄糖耐受不良有关。此外，在产前经历过饥荒的女性在生育方面更成功：她们开始生育的年龄更早，有更多的孩子，更多的双胞胎，并且不太可能没有孩子。产前接触饥荒的影响似乎并不局限于那些在产前接触饥荒的人：而且，他们的孩子似乎更不健康。这些研究结果表明，孕妇在妊娠期间营养不良对以后的健康有重要影响，但对健康的影响取决于妊娠期间的时间。妊娠早期似乎是一个特别脆弱的时期。在怀孕前和怀孕期间向妇女提供适当的饮食建议似乎是预防后代慢性疾病的一种有希望的策略。
This paper describes the findings from a cohort study of 2,414 people born around the time of the Dutch famine. We found more coronary heart disease, a more atherogenic lipid profile, disturbed blood coagulation, and increased stress responsiveness among those exposed to famine in early gestation. Women exposed to famine in early gestation were more obese and had an increased risk of breast cancer. People exposed to famine in mid gestation had more microalbuminuria and obstructive airway disease. Exposure to famine during any stage of gestation was associated with glucose intolerance. Also, women who had been exposed to famine prenatally were more reproductively successful: they started reproducing at an earlier age, had more children, more twins, and were less likely to remain childless. The effects of prenatal famine exposure did not appear to be restricted to those exposed to it prenatally: also, their children appeared to be less healthy. These findings show that maternal undernutrition during gestation has important effects on health in later life, but that the effects on health depend on its timing during gestation. Early gestation seems to be an especially vulnerable period. Adequate dietary advice to women before and during pregnancy seems a promising strategy in preventing chronic diseases in future generations.