Withdrawal Syndrome with Methaqualone
Withdrawal Syndrome with Methaqualone
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DOI：
10.1080/02791072.1972.10471474
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发表时间：
1972-09
影响因子：
2.8
通讯作者：
S. Schnoll;R. Fishkin
中科院分区：
文献类型：
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作者：
S. Schnoll;R. Fishkin
由于许多甲喹酮使用者同时服用其他药物，特别是其他镇静催眠药，很难确定我们之前看到的戒断综合征是由于甲喹酮还是其他药物。然而，由于安眠酮变得更容易通过医生的处方获得，这些医生并不知道它的滥用潜力和增加的非法来源，我们开始对只使用安眠酮的个人进行检查。在病例中，在甲喹酮戒断时未使用其他已报告戒断综合征的镇静催眠药。病例1证实了巴比妥类药物和甲喹酮之间存在交叉耐受性，使用户能够根据哪种药物的供应量更大而互换使用该药物。Madden报告了一个类似的案例。2.在停用安眠酮的患者中最常见的综合征包括头痛、厌食、恶心和腹部绞痛，如病例1和病例3所述。夜惊和幻觉并不常见，但在停用较高剂量的患者中也观察到。病例2所示的戒断症状可通过逐渐停用药物来减轻，每天减少150 mg剂量。
D IS CUS SIO NSince manv methaqualone users take other drugs simultaneously, particularly other sedative hypnotics, it was difficult to determine if the withdrawal syndrome we had been seeing earlier was due to methaqualone or other drugs. llowcver, as methaqualone became more readily available through prescriptions from physicians who were not aware of its abuse potential and increasing illegitimate sources, we began to sec individuals using methaqualone exclusively. In the cases presented no other sedative hypnotics for which withdrawal syndromes have been reported were being used at the time of methaqualone withdrawal. Case 1 exemplifies the cross tolerance which exists between barbiturates and methaqualone, enabling users to use the drug interchangeably depending upon which is in greater supply. A similar case was reported by Madden. 2 The syndrome seen most frequently in patients withdrawing from methaqualone consists of headache, anorexia, nausea and abdominal cramps as described in cases 1 and 3. Nightrnarcs and hallucinations are not seen as frequently, but have been noted in patients withdrawing from higher doses. The withdrawal symptoms as demonstrated in Case 2 can be attenuated by gradually withdrawing the patient from the drug, reducing the dose by 150 mg a day.