The hippocampus and contextual memory retrieval in Pavlovian conditioning
The hippocampus and contextual memory retrieval in Pavlovian conditioning
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DOI：
10.1016/s0166-4328(99)00188-6
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发表时间：
2000-06-01
影响因子：
2.7
通讯作者：
Holt, W
中科院分区：
文献类型：
--
作者：
Maren, S;Holt, W
一些关于海马功能的理论已经表明海马在上下文记忆提取中的作用。然而，这些理论是基于永久性训练前损伤的研究，混淆了海马在学习中的作用和在提取中的作用。我们认为，需要另一种方法来评估海马在记忆提取过程中的作用。这种替代方法涉及暂时失活的海马在巴甫洛夫范式，借给自己的检索检查。这种方法的一个例子被认为是在巴甫洛夫恐惧条件反射范式。我们研究了海马失活对潜抑制的上下文特异性表达的影响，当兴奋性条件反射之前由非增强的呈现被条件刺激时，显示的反应递减。可逆失活的背海马检索测试之前消除了特定的上下文表达的潜在抑制。海马的检索过程中的作用的性质进行了讨论，根据这些数据。(C)2000 Elsevier Science B.V.保留所有权利。
Several theories of hippocampal function have suggested a role for the hippocampus in contextual memory retrieval. However, these theories are based on studies using permanent pretraining lesions, which confound the role of the hippocampus in learning with its role in retrieval. We argue that an alternative methodology is required to assess the role of the hippocampus in memory retrieval processes. This alternative methodology involves temporary inactivation of the hippocampus in Pavlovian paradigms that lend themselves to an examination of retrieval. An example of this approach is considered in a Pavlovian fear-conditioning paradigm. We examined the influence of hippocampal inactivation on the context-specific expression of latent inhibition, a response decrement displayed when excitatory conditioning is preceded by non-reinforced presentations of a to-be-conditioned stimulus. Reversible inactivation of the dorsal hippocampus prior to retrieval testing eliminated the context-specific expression of latent inhibition. The nature of the hippocampal role in retrieval processes is discussed in the light of these data. (C) 2000 Elsevier Science B.V. All rights reserved.