AMONG NAIVE PRECURSOR CELL SUBPOPULATIONS ONLY PROGENITORS OF MEMORY B-CELLS ORIGINATE GERMINAL-CENTERS
AMONG NAIVE PRECURSOR CELL SUBPOPULATIONS ONLY PROGENITORS OF MEMORY B-CELLS ORIGINATE GERMINAL-CENTERS
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DOI：
10.1002/eji.1830220526
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发表时间：
1992-05-01
影响因子：
5.4
通讯作者：
KLINMAN, NR
中科院分区：
文献类型：
--
作者：
LINTON, PJ;LO, D;KLINMAN, NR
免疫导致抗体形成细胞（AFC）和记忆B细胞的产生，这些细胞被认为是在淋巴滤泡内的生发中心产生的。记忆B细胞的前体存在于非免疫小鼠脾脏的J11 D（lo）亚群中，并且该亚群不同于传统的AFC前体，包括CD 5 + B细胞，这一发现表明，生发中心的前体也可能存在于J11 D（lo）亚群中。为了检验这一假设，用CD 4+载体致敏的T细胞和T耗尽的J11 D（lo）、J11 D（hi）或CD 5 + B细胞再增殖SCID小鼠，并用半抗原-载体缀合物免疫。只有J11 D（lo）群体富集产生生发中心的细胞。因此，产生记忆B细胞的前体细胞亚群也起源于生发中心。
Immunization leads to the generation of both antibody-forming cells (AFC) and memory B cells which are thought to arise in germinal centers within lymphoid follicles. The findings that the precursors to memory B cells reside in the J11D(lo) subpopulation of the spleens in non-immune mice and that this subpopulation is distinct from conventional AFC precursors, including CD5+ B cells, suggest that the precursors of germinal centers might also reside in the J11D(lo) subpopulation. To test this hypothesis, SCID mice were repopulated with CD4+ carrier-primed T cells and T-depleted J11D(lo), J11D(hi) or CD5+ B cells and immunized with a hapten-carrier conjugate. Only the J11D(lo) population was enriched for cells that produced germinal centers. Thus, the subpopulation of precursors that generates memory B cells also originates germinal centers.