Coagulopathy associated with hematin treatment for acute intermittent porphyria.
Coagulopathy associated with hematin treatment for acute intermittent porphyria.
复制标题
与血红素治疗急性间歇性卟啉症相关的凝血障碍。
DOI：
--
复制
发表时间：
1981
影响因子：
39.2
通讯作者：
R. Pearson
中科院分区：
文献类型：
--
作者：
D. Morris;M. Dudley;R. Pearson
血红素已被证明是治疗急性间歇性卟啉症的有效方法。几乎没有发现并发症。我们治疗的一名患者在接受血红素治疗时出现凝血酶原时间、部分凝血活酶时间明显延长、血小板减少、轻度低纤维蛋白原血症、纤维蛋白裂解产物轻度升高以及血细胞比容下降 10%。没有发现凝血障碍的其他原因。停止使用血红素后，异常的凝血指标恢复正常。因急性间歇性卟啉症而接受血红素治疗的患者应密切观察凝血功能障碍的体征。
Hematin has been shown to be effective therapy for acute intermittent porphyria. Few complications have been found. We cared for a patient who developed a markedly prolonged prothrombin time, partial thromboplastin time, thrombocytopenia, mild hypofibrinogenemia, mild elevation of fibrin split products, and a 10% fall in hematocrit while receiving hematin. No other cause for the coagulopathy could be found. The abnormal coagulation variables returned to normal when hematin was discontinued. Patients receiving hematin for acute intermittent porphyria should be closely observed for signs of coagulopathy.