Acute phase proteins in animals.
Acute phase proteins in animals.
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DOI：
10.1016/b978-0-12-394596-9.00005-6
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发表时间：
2012
影响因子：
--
通讯作者：
Cray C
中科院分区：
文献类型：
--
作者：
Cray C
急性时相蛋白(APP)在20世纪初首次被鉴定为传染病的早期反应物。它们现在被认为是急性时相反应(APR)的组成部分，而APR是天然免疫的基石。APP已被证明是有价值的生物标志物，因为炎症、感染、肿瘤、应激和创伤都会导致APP升高。所有动物--从鱼类到哺乳动物--都有明显的APP，但主要APP的类型因物种而异。虽然这些蛋白质在临床环境中的主要应用是预测，但在动物身上的研究已经证明与亚临床疾病的诊断、检测和监测有关。APP已经在实验室、同伴和大型动物中得到了很好的证明。随着标准化和自动化分析的出现，这些生物标志物可用于兽医以及基础和临床研究的所有领域。
Acute phase proteins (APP) were first identified in the early 1900s as early reactants to infectious disease. They are now understood to be an integral part of the acute phase response (APR) which is the cornerstone of innate immunity. APP have been shown to be valuable biomarkers as increases can occur with inflammation, infection, neoplasia, stress, and trauma. All animals—from fish to mammals—have demonstrable APP, but the type of major APP differs by species. While the primary application of these proteins in a clinical setting is prognostication, studies in animals have demonstrated relevance to diagnosis and detection and monitoring for subclinical disease. APP have been well documented in laboratory, companion, and large animals. With the advent of standardized and automated assays, these biomarkers are available for use in all fields of veterinary medicine as well as basic and clinical research.