Metabolic brain networks associated with cognitive function in Parkinson's disease
Metabolic brain networks associated with cognitive function in Parkinson's disease
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DOI：
10.1016/j.neuroimage.2006.09.003
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发表时间：
2007-01-15
期刊：
影响因子：
5.7
通讯作者：
Eidelberg, David
中科院分区：
文献类型：
--
作者：
Huang, Chaorui;Mattis, Paul;Eidelberg, David
帕金森病（PD）的运动表现与涉及基底神经节丘脑皮质通路的异常空间协方差模式有关。相比之下，对这种疾病中认知功能障碍的功能网络知之甚少。为了识别这种模式，我们研究了15名非痴呆PD患者使用FDG PET和基于体素的网络建模方法。我们检测到一个显着的协方差模式，相关（p < 0.01）与记忆和执行功能测试的性能。这种PD相关的认知模式（PDCP）的特点是额叶和顶叶联合区的代谢减少和小脑蚓部和齿状核的相对增加。为了验证这一模式，我们分析了32名年龄、疾病持续时间和严重程度相似的后续PD患者的数据。在该验证样本中，对PDCP活动的前瞻性测量预测了记忆性能（p < 0.005）、视觉空间功能（p < 0.01）和感知运动速度（p < 0.005）。在间隔8周重复FDG PET的患者中，PDCP评分还显示出良好的重测信度（组内相关系数，ICC=0.89）。与PD相关的运动模式不同，静脉注射左旋多巴或脑深部电刺激（DBS）抗帕金森病治疗并未显著改变PDCP表达。这些发现证实了PDCP作为PD认知功能的可重复成像标志物。由于PDCP的表达不改变常规抗帕金森病治疗，这种网络活动的措施可能会被证明是有用的，在临床试验中针对这种疾病的非运动表现的进展。(c)2006年爱思唯尔公司All rights reserved.
The motor manifestations of Parkinson's disease (PD) have been linked to an abnormal spatial covariance pattern involving basal ganglia thalamocortical pathways. By contrast, little is known about the functional networks that underlie cognitive dysfunction in this disorder. To identify such patterns, we studied 15 non-demented PD patients using FDG PET and a voxel-based network modeling approach. We detected a significant covariance pattern that correlated (p < 0.01) with performance on tests of memory and executive functioning. This PD-related cognitive pattern (PDCP) was characterized by metabolic reductions in frontal and parietal association areas and relative increases in the cerebellar vermis and dentate nuclei. To validate this pattern, we analyzed data from 32 subsequent PD patients of similar age, disease duration and severity. Prospective measurements of PDCP activity predicted memory performance (p < 0.005), visuospatial function (p < 0.01), and perceptual motor speed (p < 0.005) in this validation sample. PDCP scores additionally exhibited an excellent degree of test-retest reliability (intraclass correlation coefficient, ICC=0.89) in patients undergoing repeat FDG PET at an 8-week interval. Unlike the PD-related motor pattern, PDCP expression was not significantly altered by antiparkinsonian treatment with either intravenous levodopa or deep brain stimulation (DBS). These findings substantiate the PDCP as a reproducible imaging marker of cognitive function in PD. Because PDCP expression is not altered by routine antiparkinsonian treatment, this measure of network activity may prove useful in clinical trials targeting the progression of non-motor manifestations of this disorder. (c) 2006 Elsevier Inc. All rights reserved.