Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.
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DOI：
10.1038/bjc.1991.124
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发表时间：
1991-04
影响因子：
8.8
通讯作者：
Sekiguchi M
中科院分区：
文献类型：
--
作者：
Yanagië H;Tomita T;Kobayashi H;Fujii Y;Takahashi T;Hasumi K;Nariuchi H;Sekiguchi M
一种含10b化合物的免疫脂质体已被研究作为硼中子捕获治疗的选择性药物递送系统。与癌胚抗原（CEA）特异性单克隆抗体结合的脂质体可以选择性地与表面携带癌胚抗原的细胞结合。附着于肿瘤细胞的免疫脂质体在体外热中子照射下抑制肿瘤细胞的生长，这种抑制取决于脂质体中10b化合物的浓度和与脂质体偶联的抗体的密度。结果表明，含10B化合物的免疫脂质体可以作为10B原子的选择性和高效载体，在硼中子捕获治疗中靶向肿瘤细胞。
An immunoliposome containing a 10B-compound has been examined as a selective drug delivery system in boron neutron-capture therapy. Liposomes, conjugated with monoclonal antibodies specific for carcinoembryonic antigen (CEA) were shown to bind selectively to cells bearing CEA on their surface. The immunoliposomes attached to tumour cells suppressed growth in vitro upon thermal neutron irradiation and suppression was dependent upon the concentration of the 10B-compound in the liposomes and on the density of antibody conjugated to the liposomes. The results suggest that immunoliposomes containing the 10B-compound could act as a selective and efficient carrier of 10B atoms to target tumour cells in boron neutron-capture therapy.