Ulcerative Colitis and Cancer
Ulcerative Colitis and Cancer
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DOI：
10.1002/jso.21505
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发表时间：
2010-06-15
影响因子：
2.5
通讯作者：
Dayton, Merril T.
中科院分区：
文献类型：
--
作者：
Kulaylat, Mahmoud N.;Dayton, Merril T.
溃疡性结肠炎(UC)患者患结直肠癌(CRC)的风险增加。与散发性CRC不同，UC患者的癌症起源于炎症区域的局灶性或多灶性粘膜发育不良。UC相关癌的临床特征与遗传性非息肉病性结直肠癌患者相似。与其他类型的结直肠癌一样，UC相关癌症表现出各种基因和分子变化/异常。然而，这些异常集中在有组织学异常的粘膜区域。然而，这些变化的幅度和时间都有很大不同。监测和识别癌症高危患者是一个具有挑战性的问题。J·奥科尔外科医生。2010；101：706-712。(C)2010年Wiley-Liss公司
Patients with ulcerative colitis (UC) are at an increased risk for the development of colorectal cancer (CRC). Unlike sporadic CRC, the cancer in UC patients arises from a focal or multifocal dysplastic mucosa in areas of inflammation. The clinical features of UC-associated cancer are similar to those found in patients with hereditary non-polyposis colorectal cancer. As with other varieties of CRC, UC-associated cancer exhibits a variety of genetic and molecular changes/abnormalities. These abnormalities are however clustered in areas of mucosae with histological abnormalities. The magnitude and timing of these changes are however significantly different. Surveillance and identification of patients at risk for cancer are a challenging problem. J. Surg. Oncol. 2010;101:706-712. (C) 2010 Wiley-Liss, Inc.