MOVEMENT AS AN INDEX OF VITALITY - COMPARING WILD-TYPE AND THE AGE-1 MUTANT OF CAENORHABDITIS-ELEGANS
MOVEMENT AS AN INDEX OF VITALITY - COMPARING WILD-TYPE AND THE AGE-1 MUTANT OF CAENORHABDITIS-ELEGANS
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DOI：
10.1093/gerona/50a.5.b254
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发表时间：
1995-09-01
影响因子：
5.1
通讯作者：
JOHNSON, TE
中科院分区：
文献类型：
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作者：
DUHON, SA;JOHNSON, TE
我们已经问是否年龄-1基因的突变形式，延长线虫的寿命长达70%的秀丽隐杆线虫，也影响轮胎的移动能力，在这个延长的生命周期。年龄-1突变体和野生型对照显示线性损失的运动作为线虫的年龄。年龄-1突变株在生命早期比非年龄株移动得更快，并且在年龄较大时比非年龄株继续低的移动速率。一般来说，运动率并不能很好地预测以后任何年龄或寿命的运动率。个人的累积寿命运动高度相关，因此是一个很好的预测，个人寿命。这些发现与早期对长寿的重组-近交的C. elegans，并暗示由年龄-1突变改变的生理过程导致在以后的生活中增加的健康，如通过增加的移动能力所监测的。
We have asked whether the mutant form of the age-1 gene, which lengthens the life span of the nematode Caenorhabditis elegans up to 70%, also affects tire ability to move during this extended period of life. Both age-1 mutants and wild-type controls display a linear loss of movement as the nematodes age. age-1 mutant strains moved faster early in life when compared with non-Age strains and continued low rates of movement at older ages than did non-Age strains. Movement rates were not, in general, a good predictor of movement rates at any later age or of life span. Cumulative lifetime movements of individuals were highly correlated with, and thus a good predictor of, individual life span. These findings are similar to earlier studies of movement in long-lived recombinant-inbred strains of C. elegans and imply that the physiological process altered by the age-1 mutation results in increased health during later life as monitored by increased ability to move.